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Effect of cyp2c9*3 allele on the pharmacokinetics of naproxen in korean subjects

Academic Article
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Overview

authors

  • Bae, J. W.
  • Kim, J. H.
  • Choi, C. I.
  • Kim, M. J.
  • Kim, H. J.
  • Byun, S. A.
  • Chang, Y. S.
  • Jang, Choon-Gon
  • Park, Y. S.
  • Lee, S. Y.

publication date

  • February 2009

journal

  • Archives of Pharmacal Research  Journal

abstract

  • The genetically polymorphic CYP2C9 metabolizes many non-steroidal anti-inflammatory agents, including naproxen. This study examined the effects of a CYP2C9 genetic polymorphism on the pharmacokinetics of naproxen in Korean subjects. Twenty healthy male subjects carrying a CYP2C9*1/*1 (n=14) or CYP2C9*1/*3 (n=6) polymorphism were enrolled. After a single-dose of 275 mg naproxen Na, blood samples were collected at various times over a 72 h period and the plasma naproxen concentration was measured. The plasma concentration of naproxen was determined by HPLC analysis with UV detection, and the pharmacokinetic parameters were calculated. The mean plasma concentration-time profiles of naproxen in the CYP2C9*1/*3 and CYP2C9*1/*1 individuals were similar. There were no significant differences in the pharmacokinetics of naproxen between CYP2C9*1/*1 and CYP2C9*1/*3 genotypes. The AUC(0-infinity) (p = 0.759) and oral clearance (p = 0.823) of naproxen were also similar in individuals with CYP2C9*1/*3 and CYP2C9*1/*1. Overall, a genetic polymorphism of CYP2C9 does not significantly affect the pharmacokinetics of naproxen. Therefore, naproxen does not require a dose adjustment for individuals with the CYP2C9*1/*3 genotype.

subject areas

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal
  • Area Under Curve
  • Aryl Hydrocarbon Hydroxylases
  • Chromatography, High Pressure Liquid
  • Cytochrome P-450 CYP2C9
  • Genotype
  • Humans
  • Korea
  • Male
  • Metabolic Detoxication, Phase I
  • Naproxen
  • Polymorphism, Genetic
  • Young Adult
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Research

keywords

  • Allele
  • CYP2C9
  • Genotype
  • Naproxen
  • Pharmacokinetics
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Identity

International Standard Serial Number (ISSN)

  • 0253-6269

Digital Object Identifier (DOI)

  • 10.1007/s12272-009-1232-z

PubMed ID

  • 19280158
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Additional Document Info

start page

  • 269

end page

  • 273

volume

  • 32

issue

  • 2

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