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Advances in pain therapeutics

Academic Article
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Overview

authors

  • LoGrasso, Philip
  • McKelvy, J.

publication date

  • August 2003

journal

  • Current Opinion in Chemical Biology  Journal

abstract

  • Recent work in defining molecular targets for neuropathic pain has been plentiful and varied. Three novel targets have received much attention recently: N-methyl-D-aspartate receptor subtypes such as the glycine and NR2B sites, and the tetrodotoxin-resistant voltage-gated sodium channel (Na(v) 1.8; SNS/PN3). Preclinical data have been encouraging as a number of selective NR2B and glycine site antagonists have shown efficacy in animal models. Selective Na(v) 1.8 channel blockers have yet to emerge; however, strong genetic evidence and data from non-selective Na channel blockers indicate that this target too may hold much promise.

subject areas

  • Anesthetics, Local
  • Animals
  • Binding Sites
  • Glycine
  • Humans
  • Molecular Structure
  • NAV1.9 Voltage-Gated Sodium Channel
  • Neuropeptides
  • Pain
  • Receptors, N-Methyl-D-Aspartate
  • Sodium Channel Blockers
  • Sodium Channels
  • Tetrodotoxin
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Identity

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/s1367-5931(03)00078-4

PubMed ID

  • 12941418
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Additional Document Info

start page

  • 452

end page

  • 456

volume

  • 7

issue

  • 4

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