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The relative efficiency and power of small-pedigree studies of the heritability of a quantitative trait

Academic Article
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Overview

authors

  • Schork, Nicholas
  • Schork, M. A.

publication date

  • January 1993

journal

  • Human Heredity  Journal

abstract

  • Methods to determine the proportion of variability manifested by a quantitative trait that is attributable to additive genetic effects are important tools for human population and statistical geneticists. Though traditional methods based on parent-offspring and sib-pair correlations have been well researched, they are being steadily supplanted or complemented by more powerful pedigree-based variance-component techniques. In this paper, a theoretical investigation of the relative efficiency and power of small (i.e., < 10 members) variance-component pedigree designs for heritability estimation is undertaken. The information gain in adding sibs and generations to pedigrees is discussed. Sample size guidelines based on theoretical power functions are offered, as are directions for future research.

subject areas

  • Genetics, Medical
  • Humans
  • Pedigree
  • Phenotype
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Research

keywords

  • HERITABILITY ESTIMATION
  • QUANTITATIVE GENETICS
  • RELATIVE EFFICIENCY
  • SAMPLE SIZE
  • VARIANCE COMPONENTS
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Identity

International Standard Serial Number (ISSN)

  • 0001-5652

Digital Object Identifier (DOI)

  • 10.1159/000154106

PubMed ID

  • 8514319
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Additional Document Info

start page

  • 1

end page

  • 11

volume

  • 43

issue

  • 1

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