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Unexpected autoantibody production in membrane ig-mu-deficient/lpr mice

Academic Article
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Overview

authors

  • Melamed, D.
  • Miri, E.
  • Leider, N.
  • Nemazee, David

publication date

  • October 2000

journal

  • Journal of Immunology  Journal

abstract

  • In the B lymphocyte lineage, Fas-mediated cell death is important in controlling activated mature cells, but little is known about possible functions at earlier developmental stages. In this study we found that in mice lacking the IgM transmembrane tail exons (muMT mice), in which B cell development is blocked at the pro-B stage, the absence of Fas or Fas ligand allows significant B cell development and maturation, resulting in high serum Ig levels. These B cells demonstrate Ig heavy chain isotype switching and autoimmune reactivity, suggesting that lack of functional Fas allows maturation of defective and/or self-reactive B cells in muMT/lpr mice. Possible mechanisms that may allow maturation of these B cells are discussed.

subject areas

  • Agammaglobulinemia
  • Animals
  • Antigens, CD95
  • Autoantibodies
  • B-Lymphocyte Subsets
  • Bone Marrow Cells
  • Cell Differentiation
  • Immunoglobulin M
  • Immunoglobulin mu-Chains
  • Immunoglobulins
  • Immunophenotyping
  • Lymph Nodes
  • Lymphatic Diseases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred MRL lpr
  • Mice, Mutant Strains
  • Receptors, Antigen, B-Cell
  • Signal Transduction
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 11035071
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Additional Document Info

start page

  • 4353

end page

  • 4358

volume

  • 165

issue

  • 8

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