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Consequences of secondary or coinfections for immunity

Academic Article
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Overview

authors

  • Mosier, Donald

publication date

  • August 1994

journal

  • Current Opinion in Immunology  Journal

abstract

  • While remarkable progress has been made using genetically altered mice to understand the importance of different cytokines in protecting against experimental infections or co-infections, an examination of the opportunistic infections that occur during HIV infection of humans does not yet show a clear picture of cytokine imbalance. Opportunistic infections appear to result from impairments in cells mediating innate resistance, such as natural killer cells, macrophages, and neutrophils. Some of these defects may not be corrected even if CD4+ T cells were suddenly restored to normal. The lessons from immunodeficient and gene knockout mice now need to be put to the test in the clinic.

subject areas

  • AIDS-Related Opportunistic Infections
  • Animals
  • CD4-Positive T-Lymphocytes
  • Cytokines
  • HIV Infections
  • Humans
  • Immunity
  • Killer Cells, Natural
  • Mice
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Identity

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/0952-7915(94)90138-4

PubMed ID

  • 7946040
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Additional Document Info

start page

  • 539

end page

  • 544

volume

  • 6

issue

  • 4

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