Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Broadly neutralizing monoclonal antibodies 2f5 and 4e10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus shivba-l

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Hessell, A. J.
  • Rakasz, E. G.
  • Tehrani, D. M.
  • Huber, M.
  • Weisgrau, K. L.
  • Landucci, G.
  • Forthal, D. N.
  • Koff, W. C.
  • Poignard, Pascal
  • Watkins, D. I.
  • Burton, Dennis

publication date

  • February 2010

journal

  • Journal of Virology  Journal

abstract

  • The membrane-proximal external region (MPER) of HIV-1, located at the C terminus of the gp41 ectodomain, is conserved and crucial for viral fusion. Three broadly neutralizing monoclonal antibodies (bnMAbs), 2F5, 4E10, and Z13e1, are directed against linear epitopes mapped to the MPER, making this conserved region an important potential vaccine target. However, no MPER antibodies have been definitively shown to provide protection against HIV challenge. Here, we show that both MAbs 2F5 and 4E10 can provide complete protection against mucosal simian-human immunodeficiency virus (SHIV) challenge in macaques. MAb 2F5 or 4E10 was administered intravenously at 50 mg/kg to groups of six male Indian rhesus macaques 1 day prior to and again 1 day following intrarectal challenge with SHIV(Ba-L). In both groups, five out of six animals showed complete protection and sterilizing immunity, while for one animal in each group a low level of viral replication following challenge could not be ruled out. The study confirms the protective potential of 2F5 and 4E10 and supports emphasis on HIV immunogen design based on the MPER region of gp41.

subject areas

  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • Enzyme-Linked Immunosorbent Assay
  • HIV Envelope Protein gp41
  • HIV-1
  • HeLa Cells
  • Humans
  • Immunity, Mucosal
  • Simian Immunodeficiency Virus
  • Viral Load
scroll to property group menus

Identity

PubMed Central ID

  • PMC2812338

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.01272-09

PubMed ID

  • 19906907
scroll to property group menus

Additional Document Info

start page

  • 1302

end page

  • 1313

volume

  • 84

issue

  • 3

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support