recent publications

• academic article

  • Seki, H., Xue, S., Hixon, M. S., Pellett, S., Remes, M., Johnson, E. A., Janda, K. D. Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity Chemical Communications  2015 51:6226-6229  DOI:10.1039/c5cc00677e  PMID:25759983
  • Harris, T. L., Lowery, C. A., Hixon, M. S., Janda, K. D. A platform stratifying a sequestering agent and a pharmacological antagonist as a means to negate botulinum neurotoxicity ACS Chemical Neuroscience  2014 5:632-636  DOI:10.1021/cn500135h  PMID:25000171  PMCID:PMC4140587
  • Xue, S., Javor, S., Hixon, M. S., Janda, K. D. Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity Biochemistry  2014 53:6820-6824  DOI:10.1021/bi500950x  PMID:25295706  PMCID:PMC4222541
  • Zhu, J., Hixon, M. S., Globisch, D., Kaufmann, G. F., Janda, K. D. Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation Journal of the American Chemical Society  2013 135:7827-7830  DOI:10.1021/ja4024989  PMID:23672516  PMCID:PMC3736694
  • Globisch, D., Moreno, A. Y., Hixon, M. S., Nunes, A. A., Denery, J. R., Specht, S., Hoerauf, A., Janda, K. D. Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness Proceedings of the National Academy of Sciences of the United States of America  2013 110:4218-4223  DOI:10.1073/pnas.1221969110  PMID:23440222  PMCID:PMC3600455
  • Cai, X., Whitfield, T., Hixon, M. S., Grant, Y., Koob, G. F., Janda, K. D. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design Journal of Medicinal Chemistry  2013 56:3701-3709  DOI:10.1021/jm400228w  PMID:23627877  PMCID:PMC3691275
  • Cai, X., Whitfield, T., Moreno, A. Y., Grant, Y., Hixon, M. S., Koob, G. F., Janda, K. D. Probing the effects of hapten stability on cocaine vaccine immunogenicity Molecular Pharmaceutics  2013 10:4176-4184  DOI:10.1021/mp400214w  PMID:23927436  PMCID:PMC3946501
  • Silhar, P., Lardy, M. A., Hixon, M. S., Shoemaker, C. B., Barbieri, J. T., Struss, A. K., Lively, J. M., Javor, S., Janda, K. D. The C-terminus of botulinum A protease has profound and unanticipated kinetic consequences upon the catalytic cleft ACS Medicinal Chemistry Letters  2013 4:283-287  DOI:10.1021/ml300428s  PMID:23565325  PMCID:PMC3615567
  • Salzameda, N. T., Eubanks, L. M., Zakhari, J. S., Tsuchikama, K., DeNunzio, N. J., Allen, K. N., Hixon, M. S., Janda, K. D. A cross-over inhibitor of the botulinum neurotoxin light chain B: A natural product implicating an exosite mechanism of action Chemical Communications  2011 47:1713-1715  DOI:10.1039/c0cc04078a  PMID:21203627  PMCID:PMC3065946
  • Zakhari, J. S., Kinoyama, I., Hixon, M. S., Di Mola, A., Globisch, D., Janda, K. D. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization Bioorganic & Medicinal Chemistry  2011 19:6203-6209  DOI:10.1016/j.bmc.2011.09.019  PMID:21975066  PMCID:PMC3196298
  • Eubanks, L. M., Stowe, G. N., Marin, S. D., Mayorov, A. V., Hixon, M. S., Janda, K. D. Identification of alpha(2) macroglobulin as a major serum ghrelin esterase Angewandte Chemie-International Edition  2011 50:10699-10702  DOI:10.1002/anie.201104512  PMID:21928452  PMCID:PMC3515674
  • Barbieri, J. T., Pellett, S., Capkova, K., Hixon, M. S., Janda, K. D., Johnson, E. A. Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase Bioorganic & Medicinal Chemistry Letters  2010 20:206-208  DOI:10.1016/j.bmcl.2009.10.129  PMID:19914829  PMCID:PMC2818383
  • Silhar, P., Capkova, K., Salzameda, N. T., Barbieri, J. T., Hixon, M. S., Janda, K. D. Botulinum neurotoxin a protease: Discovery of natural product exosite inhibitors Journal of the American Chemical Society  2010 132:2868-2869  DOI:10.1021/ja910761y  PMID:20158239  PMCID:PMC2832098
  • Stowe, G. N., Silhar, P., Hixon, M. S., Silvaggi, N. R., Allen, K. N., Moe, S. T., Jacobson, A. R., Barbieri, J. T., Janda, K. D. Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype A protease Organic Letters  2010 12:756-759  DOI:10.1021/ol902820z  PMID:20092262  PMCID:PMC2821465
  • Eubanks, L. M., Silhar, P., Salzameda, N. T., Zakhari, J. S., Xiaochuan, F., Barbieri, J. T., Shoemaker, C. B., Hixon, M. S., Janda, K. D. Identification of a natural product antagonist against the botulinum neurotoxin light chain protease ACS Medicinal Chemistry Letters  2010 1:268-272  DOI:10.1021/ml100074s  PMID:20959871  PMCID:PMC2955888
  • Denery, J. R., Nunes, A. A. K., Hixon, M. S., Dickerson, T. J., Janda, K. D. Metabolomics-based discovery of diagnostic biomarkers for onchocerciasis PLoS Neglected Tropical Diseases  2010 4:e834  DOI:10.1371/journal.pntd.0000834  PMID:20957145  PMCID:PMC2950146
  • Mayorov, A. V., Amara, N., Chang, J. Y., Moss, J. A., Hixon, M. S., Ruiz, D. I., Meijler, M. M., Zorrilla, E. P., Janda, K. D. Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice Proceedings of the National Academy of Sciences of the United States of America  2008 105:17487-17492  DOI:10.1073/pnas.0711808105  PMID:18981425  PMCID:PMC2582297
  • Capkova, K., Hixon, M. S., McAllister, L. A., Janda, K. D. Toward the discovery of potent inhibitors of botulinum neurotoxin a: Development of a robust lc ms based assay operational from low to subnanomolar enzyme concentrations Chemical Communications  2008 3525-3527  DOI:10.1039/b808305c  PMID:18654701
  • Dickerson, T. J., Clancy, C. M., Johnson, E. A., Baldwin, M. R., Jin, W., Barbieri, J. T., Tepp, W. H., Eubanks, L. M., Malizio, C. J., Goodnough, M. C., Janda, K. D., Hong, S., et al. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists Proceedings of the National Academy of Sciences of the United States of America  2007 104:2602-2607  DOI:10.1073/pnas.0611213104  PMID:17293454  PMCID:PMC1815229
  • Xu, Y., Hixon, M. S., Yamamoto, N., McAllister, L. A., Wentworth, A. D., Wentworth, P., Janda, K. D. Antibody-catalyzed anaerobic destruction of methamphetamine Proceedings of the National Academy of Sciences of the United States of America  2007 104:3681-3686  DOI:10.1073/pnas.0611094104  PMID:17360412  PMCID:PMC1820643
  • Xu, Y., Hixon, M. S., Dawson, P. E., Janda, K. D. Development of a FRET assay for monitoring of HIV gp41 core disruption Journal of Organic Chemistry  2007 72:6700-6707  DOI:10.1021/jo070836l  PMID:17685571
  • McKenzie, K. M., Mee, J. M., Rogers, C. J., Hixon, M. S., Kaufmann, G. F., Janda, K. D. Identification and characterization of single chain anti-cocaine catalytic antibodies Journal of Molecular Biology  2007 365:722-731  DOI:10.1016/j.jmb.2006.10.031  PMID:17084858  PMCID:PMC1828637
  • Yao, Y., Dickerson, T. J., Hixon, M. S., Dyson, H. J. Nmr detection of adventitious xylose binding to the quorum-sensing protein SdiA of Escherichia coli Bioorganic & Medicinal Chemistry Letters  2007 17:6202-6205  DOI:10.1016/j.bmc1.2007.09.029  PMID:17889538
  • Silvaggi, N. R., Boldt, G. E., Hixon, M. S., Kennedy, J. P., Tzipori, S., Janda, K. D., Allen, K. N. Structures of clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility Chemistry & Biology  2007 14:533-542  DOI:10.1016/j.chembiol.2007.03.014  PMID:17524984
  • McAllister, L. A., Hixon, M. S., Schwartz, R., Kubitz, D. S., Janda, K. D. Synthesis and application of a novel ligand for affinity chromatography based removal of endotoxin from antibodies Bioconjugate Chemistry  2007 18:559-566  DOI:10.1021/bc0602984  PMID:17315943
  • Moss, J. A., Stokols, S., Hixon, M. S., Ashley, F. T., Chang, J. Y., Janda, K. D. Solid-phase synthesis and kinetic characterization of fluorogenic enzyme-degradable hydrogel cross-linkers Biomacromolecules  2006 7:1011-1016  DOI:10.1021/bm051001s  PMID:16602715  PMCID:PMC2546486
  • McAllister, L. A., Hixon, M. S., Kennedy, J. P., Dickerson, T. J., Janda, K. D. Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin Journal of the American Chemical Society  2006 128:4176-4177  DOI:10.1021/ja057699z  PMID:16568962  PMCID:PMC2529174
  • Boldt, G. E., Kennedy, J. P., Hixon, M. S., McAllister, L. A., Barbieri, J. T., Tzipori, S., Janda, K. D. Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin A inhibitors Journal of Combinatorial Chemistry  2006 8:513-521  DOI:10.1021/cc060010h  PMID:16827563  PMCID:PMC2644723
  • Dickerson, T. J., Beuscher, A. E., Hixon, M. S., Yamamoto, N., Xu, Y., Olson, A. J., Janda, K. D. Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library Biochemistry  2005 44:14845-14853  DOI:10.1021/bi051613x  PMID:16274232