Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Tazi, A.
  • Dantzer, R.
  • Lemoal, M.
  • Rivier, J.
  • Vale, W.
  • Koob, George

publication date

  • July 1987

journal

  • Regulatory Peptides  Journal

abstract

  • Corticotropin-releasing factor (CRF) has been shown to have potent central nervous system-activating effects when administered intracerebroventricularly (i.c.v.). In the present experiment, this activating effect was exaggerated by use of a stress-motivated behavioral paradigm. Low doses of CRF (0.01 and 0.1 micrograms/rat) administered i.c.v. facilitated stress-induced fighting. More importantly, alpha-helical CRF-(9-41), a CRF antagonist, blocked stress-induced fighting produced by higher levels of stress. These results suggest that CRF in the central nervous system may have a role in mediating behavioral responses to stress.

subject areas

  • Aggression
  • Animals
  • Corticotropin-Releasing Hormone
  • Electroshock
  • Male
  • Peptide Fragments
  • Rats
  • Rats, Inbred Strains
  • Stress, Physiological
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0167-0115

Digital Object Identifier (DOI)

  • 10.1016/0167-0115(87)90048-6

PubMed ID

  • 3498188
scroll to property group menus

Additional Document Info

start page

  • 37

end page

  • 42

volume

  • 18

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support