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Common 82-nucleotide sequence unique to brain-RNA

Academic Article
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Overview

authors

  • Bloom, Floyd
  • Lerner, Richard
  • Milner, R, J.
  • Sutcliffe, J. Gregor

publication date

  • 1982

journal

  • Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  Journal

abstract

  • Several randomly selected cDNA clones made from rat brain polyA+RNA have unusual properties. Although the cDNA inserts are 500-1,250 base pairs long, they hybridize to a 160-nucleotide RNA species that is present in brain but not in liver or kidney. Nucleotide sequence studies of two of the clones and hybridization studies show that a common 82-nucleotide sequence is responsible for the hybridization. The same sequence is located in the second intron of a rat growth hormone gene. These studies suggest that signals called "ID sequences" may be carried in the introns of genes and prescribe their tissue-specific expression.

subject areas

  • Base Sequence
  • Brain
  • Cell Differentiation
  • DNA
  • Gene Expression Regulation
  • Nucleic Acid Hybridization
  • RNA, Messenger
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.79.16.4942

PubMed ID

  • 6956902
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Additional Document Info

start page

  • 4942

end page

  • 4946

volume

  • 79

issue

  • 16

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