recent publications
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academic article
- Rosenberg, L. H., Lafitte, M., Grant, W., Chen, W., Cleveland, J. L., Duckett, D. R. Development of an HTS-compatible assay for the discovery of Ulk1 inhibitors Journal of Biomolecular Screening 2015 20:913-920 DOI:10.1177/1087057115579391 PMID:25851035 PMCID:PMC4744088
- Yin, Y., Lin, L., Ruiz, C., Khan, S., Cameron, M. D., Grant, W., Pocas, J., Eid, N., Park, H., Schroter, T., Lograsso, P. V., Feng, Y. Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors Journal of Medicinal Chemistry 2013 56:3568-3581 DOI:10.1021/jm400062r PMID:23570561
- Chowdhury, S., Chen, Y. T., Fang, X. G., Grant, W., Pocas, J., Cameron, M. D., Ruiz, C., Lin, L., Park, H., Schroter, T., Bannister, T. D., LoGrasso, P. V., et al. Amino acid derived quinazolines as Rock/PKA inhibitors Bioorganic & Medicinal Chemistry Letters 2013 23:1592-1599 DOI:10.1016/j.bmcl.2013.01.109 PMID:23416002
- Sessions, E. H., Chowdhury, S., Yin, Y., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., LoGrasso, P., Bannister, T. D., Feng, Y. B. Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II) Bioorganic & Medicinal Chemistry Letters 2011 21:7113-7118 DOI:10.1016/j.bmcl.2011.09.084 PMID:22018789
- Chowdhury, S., Sessions, E. H., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., Schurer, S., LoGrasso, P., Bannister, T. D., Feng, Y. B. Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I) Bioorganic & Medicinal Chemistry Letters 2011 21:7107-7112 DOI:10.1016/j.bmcl.2011.09.083 PMID:22004718
- Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K. H., Shenoy, S. K., Gregory, S. G., et al. A stress response pathway regulates DNA damage through beta(2)-adrenoreceptors and beta-arrestin-1 Nature 2011 477:349-353 DOI:10.1038/nature10368 PMID:21857681 PMCID:PMC3628753
- Fang, X. A., Chen, Y. T., Sessions, E. H., Chowdhury, S., Vojkovsky, T., Yin, Y., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., et al. Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:1844-1848 DOI:10.1016/j.bmcl.2011.01.039 PMID:21349713
- Chen, Y. T., Vojkovsky, T., Fang, X. G., Pocas, J. R., Grant, W., Handy, A. M. W., Schroter, T., LoGrasso, P., Bannister, T. D., Fang, Y. B. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors MedChemComm 2011 2:73-75 DOI:10.1039/c0md00194e
- Fang, X. G., Yin, Y., Chen, Y. T., Yao, L., Wang, B., Cameron, M. D., Lin, L., Khan, S., Ruiz, C., Schroter, T., Grant, W., Weiser, A., et al. Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors Journal of Medicinal Chemistry 2010 53:5727-5737 DOI:10.1021/jm100579r PMID:20684608
- Yin, Y., Cameron, M. D., Lin, L., Khan, S., Schroter, T., Grant, W., Pocas, J., Chen, Y. T., Schurer, S., Pachori, A., LoGrasso, P., Feng, Y. B. Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats ACS Medicinal Chemistry Letters 2010 1:175-179 DOI:10.1021/ml1000382 PMID:24900192 PMCID:PMC4007833
- Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., Schroter, T., Chen, W. M., Duckett, D., Schurer, S., LoGrasso, P., Feng, Y. B. Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors Bioorganic & Medicinal Chemistry Letters 2009 19:6686-6690 DOI:10.1016/j.bmcl.2009.09.115 PMID:19837589