recent publications

• academic article

  • Jager, M., Deechongkit, S., Koepf, E. K., Nguyen, H., Gao, J. M., Powers, E. T., Gruebele, M., Kelly, J. W. Understanding the mechanism of beta-sheet folding from a chemical and biological perspective Biopolymers  2008 90:751-758  DOI:10.1002/bip.21101  PMID:18844292
  • Oza, V. B., Smith, C., Raman, P., Koepf, E. K., Lashuel, H. A., Petrassi, H. M., Chiang, K. P., Powers, E. T., Sachettinni, J., Kelly, J. W. Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors Journal of Medicinal Chemistry  2002 45:321-332  DOI:10.1021/jm010257n  PMID:11784137
  • Crane, J. C., Koepf, E. K., Kelly, J. W., Gruebele, M. Mapping the transition state of the WW domain beta-sheet Journal of Molecular Biology  2000 298:283-292  DOI:10.1006/jmbi.2000.3665  PMID:10764597
  • Koepf, E. K., Petrassi, H. M., Ratnaswamy, G., Huff, M. E., Sudol, M., Kelly, J. W. Characterization of the structure and function of W -> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding Biochemistry  1999 38:14338-14351  DOI:10.1021/bi991105l  PMID:10572009
  • Koepf, E. K., Petrassi, H. M., Sudol, M., Kelly, J. W. WW: An isolated three-stranded antiparallel β-sheet domain that unfolds and refolds reversibly; evidence for a structured hydrophobic cluster in urea and GdnHCl and a disordered thermal unfolded state Protein Science  1999 8:841-853  DOI:10.1110/ps.8.4.841  PMID:10211830  PMCID:PMC2144315