Pd(ii)-catalyzed para-selective c-h arylation of monosubstituted arenes

Academic Article
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publication date

  • September 2011

abstract

  • Pd-catalyzed highly para-selective C-H arylation of monosubstituted arenes (including toluene) is developed for the first time using an F(+) reagent as a bystanding oxidant. This finding provides a new retrosynthetic disconnection for para-substituted biaryl synthesis via C-H/C-H cross-coupling.