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The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft

Academic Article
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Overview

authors

  • Picchio, G. R.
  • Sabbe, R. E.
  • Gulizia, R. J.
  • McGrath, M.
  • Herndier, B. G.
  • Mosier, Donald

publication date

  • November 1997

journal

  • Virology  Journal

abstract

  • The body-cavity-based lymphoma cell line BCBL-1, which is infected with Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, was injected alone or with human peripheral blood mononuclear cells into SCID mice. Immunoblastic lymphomas developed at or near the site of injection. The lymphomas appeared to derive exclusively from the injected BCBL-1 cells and not from the injected human PBMC. The tumors elicited a marked murine angiogenic response, but known angiogenic cytokines were not detected in BCBL-1 cells. Transfer of BCBL-1 cells to SCID mice may represent an in vivo model for the study of KSHV/HHV8-stimulated angiogenesis.

subject areas

  • Animals
  • Antigens, CD
  • Cytokines
  • Gene Expression Regulation, Neoplastic
  • Herpesviridae Infections
  • Herpesvirus 8, Human
  • Humans
  • Immunophenotyping
  • Interleukins
  • Lymphocyte Transfusion
  • Lymphocytes
  • Mice
  • Mice, SCID
  • Neovascularization, Pathologic
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Sarcoma, Kaposi
  • Transplantation, Heterologous
  • Tumor Cells, Cultured
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Identity

International Standard Serial Number (ISSN)

  • 0042-6822

Digital Object Identifier (DOI)

  • 10.1006/viro.1997.8822

PubMed ID

  • 9375005
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Additional Document Info

start page

  • 22

end page

  • 29

volume

  • 238

issue

  • 1

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