Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Formation and biologic role of polyoma virus-antibody complexes - critical role for complement

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Oldstone, Michael
  • Cooper, N. R.
  • Larson, D. L.

publication date

  • 1974

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab complexes and not by virion lysis or attachment of large protein molecules to the V-Ab complex. In this model, binding of C1, 4, 2, 3 to the V-Ab complex may explain why some viruses concentrate in or infect certain cells bearing C3 receptors such as B lymphocytes, macrophages, and monocytes.

subject areas

  • Animals
  • Antibodies, Anti-Idiotypic
  • Antibodies, Viral
  • Antigen-Antibody Complex
  • Binding Sites, Antibody
  • Carbon Radioisotopes
  • Cattle
  • Centrifugation, Density Gradient
  • Chromatography, DEAE-Cellulose
  • Complement System Proteins
  • Cricetinae
  • Guinea Pigs
  • Humans
  • Immunodiffusion
  • Immunoelectrophoresis
  • Immunoglobulin G
  • Iodine Radioisotopes
  • Mice
  • Microscopy, Electron
  • Neutralization Tests
  • Polyomavirus
  • Rabbits
  • Thymidine
  • Tritium
  • Ultracentrifugation
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.140.2.549

PubMed ID

  • 4367757
scroll to property group menus

Additional Document Info

start page

  • 549

end page

  • 565

volume

  • 140

issue

  • 2

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support