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Thymus-grafted scid mice show transient thymopoiesis and limited depletion of v-beta-11+ t-cells

Academic Article
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Overview

authors

  • Frey, J. R.
  • Ernst, B.
  • Surh, Charles
  • Sprent, Jonathan

publication date

  • April 1992

journal

  • Journal of Experimental Medicine  Journal

abstract

  • To seek direct evidence for the notion that stem cells in the thymus need to be constantly replenished from the bone marrow (BM), fetal (day 15) thymuses from normal BALB/c mice were grafted into T and B cell-deficient C.B-17 SCID mice (both H-2d, I-E+). The thymus grafts in these mice showed normal thymopoiesis for the first 3 wk postgrafting but then developed sudden atrophy with near complete loss of CD4+8+ cells by 4-5 wk. Such atrophy was not seen when the thymus-grafted mice were cotransplanted with normal BM cells. The lymph nodes of SCID mice receiving thymus grafts alone contained mature T cells but virtually no B cells. This lack of B cells was associated with aberrant I-E-restricted V beta deletion: the depletion of V beta 3+ and V beta 5+ T cells was near complete, whereas V beta 11+ cells showed only marginal depletion.

subject areas

  • Animals
  • Antigens, CD
  • Antigens, CD4
  • Antigens, CD45
  • Antigens, CD8
  • B-Lymphocytes
  • Bone Marrow Transplantation
  • Cell Survival
  • Hematopoiesis
  • Histocompatibility Antigens
  • Lymph Nodes
  • Mice
  • Mice, SCID
  • Receptors, Antigen, T-Cell, alpha-beta
  • T-Lymphocyte Subsets
  • Thymus Gland
  • Time Factors
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Identity

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.175.4.1067

PubMed ID

  • 1532413
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Additional Document Info

start page

  • 1067

end page

  • 1071

volume

  • 175

issue

  • 4

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