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The 5-HT(5A) serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: a mechanism for neuronal suppression of reactive astrocytes

Academic Article
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Overview

authors

  • Carson, M. J.
  • Thomas, Elizabeth
  • Danielson, P. E.
  • Sutcliffe, J. Gregor

publication date

  • August 1996

journal

  • Glia  Journal

abstract

  • The mRNA for the 5-hydroxytryptamine receptor 5-HT5A was detected at embryonic day 18 in the rat central nervous system and peaked by postnatal day 20. At all time points examined, 5-HT5A immunoreactivity observed on astrocyte cell bodies and in the stellate processes not only colocalized with the astrocyte-specific marker glial fibrillary acidic protein (GFAP) but was coordinately regulated with GFAP, increasing during development and during gliosis. Transfection of 5-HT5A into glioma cells prevented the 5-HT-induced increase in cAMP observed in untransfected cells and decreased the relative forskolin response by approximately 20%, suggesting that the 5-HT5A receptor couples negatively to adenylyl cyclase in astrocytes. Together, these results indicate a neuron-to-astrocyte serotonergic signaling pathway mediating cAMP concentrations, which could provide a neuronally driven mechanism for regulating astrocyte physiology with relevance to gliosis.

subject areas

  • Aging
  • Animals
  • Animals, Newborn
  • Astrocytes
  • Cyclic AMP
  • Glial Fibrillary Acidic Protein
  • Mice
  • Neurons
  • RNA, Messenger
  • Rats
  • Receptors, Serotonin
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Research

keywords

  • gliosis
  • second messengers
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Identity

International Standard Serial Number (ISSN)

  • 0894-1491

Digital Object Identifier (DOI)

  • 10.1002/(sici)1098-1136(199608)17:4<317::aid-glia6>3.0.co;2-w

PubMed ID

  • 8856328
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Additional Document Info

start page

  • 317

end page

  • 326

volume

  • 17

issue

  • 4

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