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The genesis of high-throughput structure-based drug discovery using protein crystallography

Academic Article
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Overview

authors

  • Kuhn, Peter
  • Wilson, K.
  • Patch, M. G.
  • Stevens, Raymond

publication date

  • October 2002

journal

  • Current Opinion in Chemical Biology  Journal

abstract

  • Over the past 12 years, drugs have been developed using structure-based drug design relying upon traditional crystallographic methods. Established successes, such as the drugs designed against HIV-1 protease and neuraminidase, demonstrate the utility of a structure-based approach in the drug-discovery process. However, the approach has historically lacked throughput and reliability capabilities; these bottlenecks are being overcome by breakthroughs in high-throughput structural biology. Recent technological innovations such as submicroliter high-throughput crystallization, high-performance synchrotron beamlines and rapid binding-site analysis of de novo targets using virtual ligand screening and small molecule co-crystallization have resulted in a significant advance in structure-based drug discovery.

subject areas

  • Crystallography, X-Ray
  • Drug Design
  • Drug Evaluation, Preclinical
  • Ligands
  • Proteins
  • Structure-Activity Relationship
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Identity

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/s1367-5931(02)00361-7

PubMed ID

  • 12413557
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Additional Document Info

start page

  • 704

end page

  • 710

volume

  • 6

issue

  • 5

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