related to degree

• Newhouse, Timothy, Ph.D. in Chemistry, Scripps Research 2006 - 2010

authors

• Newhouse, Timothy
• Lewis, C. A.
• Baran, Phil

publication date

• 2009

journal

• Journal of the American Chemical Society  Journal

abstract

• Gram-scale, enantiospecific total syntheses of the anti-leukemia marine natural products kapakahines B and F have been completed. Two powerfully simplifying transformations have enabled the gram-scale synthesis of this natural product family: (1) an oxidative N-C bond-forming reaction that sets a key quaternary center with complete stereocontrol and (2) a unique strategy for the construction of twisted macrocycles via dynamic equilibration of complex late-stage intermediates.

subject areas

• Antineoplastic Agents
• Biological Products
• Macrocyclic Compounds
• Peptides, Cyclic
• Quaternary Ammonium Compounds
• Stereoisomerism

International Standard Serial Number (ISSN)

• 0002-7863

Digital Object Identifier (DOI)

• 10.1021/ja901573x

PubMed ID

• 19374357

start page

• 6360

end page

• 6361

volume

• 131

issue

• 18