recent publications

• academic article

  • Tsutakawa, S. E., Yan, C., Xu, X., Weinacht, C. P., Freudenthal, B. D., Yang, K., Zhuang, Z., Washington, M. T., Tainer, J. A., Ivanov, I. Structurally distinct ubiquitin- and SUMO-Modified PCNA: implications for their distinct roles in the DNA damage response Structure  2015 23:724-733  DOI:10.1016/j.str.2015.02.008  PMID:25773143  PMCID:PMC4394044
  • Xu, X., Jaeger, E. R., Wang, X., Lagler-Ferrez, E., Batalov, S., Mathis, N. L., Wiltshire, T., Walker, J. R., Cooke, M. P., Sauer, K., Huang, Y. H. Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration PLoS One  2014 9:e105561  DOI:10.1371/journal.pone.0105561  PMID:25133611  PMCID:PMC4136924
  • Shi, Y., Xu, X., Zhang, Q., Fu, G., Mo, Z., Wang, G. S., Kishi, S., Yang, X. L. tRNA synthetase counteracts c-Myc to develop functional vasculature Elife  2014 3:e02349  DOI:10.7554/eLife.02349  PMID:24940000  PMCID:PMC4057782
  • Wu, D. D., Zhang, F., Hao, F., Chun, J., Xu, X., Cui, M. Z. Matricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration Journal of Biological Chemistry  2014 289:5774-5783  DOI:10.1074/jbc.M113.533042  PMID:24371135  PMCID:PMC3937649
  • Xu, X., Shi, Y., Yang, X. L. Crystal structure of human seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes Structure  2013 21:2078-2086  DOI:10.1016/j.str.2013.08.021  PMID:24095058  PMCID:PMC3825832
  • Fernandez, J. A., Heeb, M. J., Xu, X., Singh, I., Zlokovic, B. V., Griffin, J. H. Species-specific anticoagulant and mitogenic activities of murine protein S Haematologica-The Hematology Journal  2009 94:1721-1731  DOI:10.3324/haematol.2009.009233  PMID:19815836  PMCID:PMC2791928
  • Yang, X. V., Banerjee, Y., Fernandez, J. A., Deguchi, H., Xu, X., Mosnier, L. O., Urbanus, R. T., de Groot, P. G., White-Adams, T. C., McCarty, O. J. T., Griffin, J. H. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells Proceedings of the National Academy of Sciences of the United States of America  2009 106:274-279  DOI:10.1073/pnas.0807594106  PMID:19116273  PMCID:PMC2629184
  • Gale, A. J., Yegneswaran, S., Xu, X., Pellequer, J. L., Griffin, J. H. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site Journal of Biological Chemistry  2007 282:21848-21855  DOI:10.1074/jbc.M702192200  PMID:17553804
  • Pecheniuk, N. M., Deguchi, H., Elias, D. J., Xu, X., Griffin, J. H. Cholesteryl ester transfer protein genotypes associated with venous thrombosis and dyslipoproteinemia in males Journal of Thrombosis and Haemostasis  2006 4:2080-2082  DOI:10.1111/j.1538-7836.2006.02099.x  PMID:16961620
  • Heeb, M. J., Schuck, P., Xu, X. Protein S multimers and monomers each have direct anticoagulant activity Journal of Thrombosis and Haemostasis  2006 4:385-391  DOI:10.1111/j.1538-7836.2006.01743.x  PMID:16420570
  • Xu, X., Kua, J., Periana, R. A., Goddard, W. A. Structure, bonding, and stability of a catalytica platinum(II) catalyst: A computational study Organometallics  2003 22:2057-2068  DOI:10.1021/om0202165
  • Fernandez, J. A., Xu, X., Liu, D., Zlokovic, B. V., Griffin, J. H. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model Blood Cells Molecules and Diseases  2003 30:271-276  DOI:10.1016/s1079-9796(03)00034-2  PMID:12737945
  • Gale, A. J., Xu, X., Pellequer, J. L., Getzoff, E. D., Griffin, J. H. Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C Protein Science  2002 11:2091-2101  DOI:10.1110/ps.0210002  PMID:12192065  PMCID:PMC2373598
  • Kua, J., Xu, X., Periana, R. A., Goddard, W. A. Stability and thermodynamics of the PtCl2 type catalyst for activating methane to methanol: A computational study Organometallics  2002 21:511-525  DOI:10.1021/om0101691
  • Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A., Lerner, R. A. Antibody catalysis of the oxidation of water Science  2001 293:1806-1811  DOI:10.1126/science.1062722  PMID:11546867
  • Xu, X., Yang, J. H., Rogus, J., Chen, C. Z., Schork, N., Xu, X. P. Mapping of a blood pressure quantitative trait locus to chromosome 15q in a chinese population Human Molecular Genetics  1999 8:2551-2555  DOI:10.1093/hmg/8.13.2551  PMID:10556304
  • Zivelin, A., Gitel, S., Griffin, J. H., Xu, X., Fernandez, J. A., Martinowitz, U., Cohen, Y., Halkin, H., Seligsohn, U., Inbal, A. Extensive venous and arterial thrombosis associated with an inhibitor to activated protein c Blood  1999 94:895-901  PMID:10419879
  • Xu, X., Bauer, K. A., Griffin, J. H. Two multiplex pcr-based DNA assays for the thrombosis risk factors prothrombin G20210A and coagulation factor V G1691A polymorphisms Thrombosis Research  1999 93:265-269  DOI:10.1016/s0049-3848(98)00178-9  PMID:10093967
  • Zivelin, A., Griffin, J. H., Xu, X., Pabinger, I., Samama, M., Conard, J., Brenner, B., Eldor, A., Seligsohn, U. A single genetic origin for a common caucasian risk factor for venous thrombosis Blood  1997 89:397-402  PMID:9002940
  • Greengard, J. S., Xu, X., Gandrille, S., Griffin, J. H. Alternative PCR method for diagnosis of mutation causing activated protein-C resistant Gln(506)-factor-V Thrombosis Research  1995 80:441-443  DOI:10.1016/0049-3848(95)00197-y  PMID:8588206
  • Greengard, J. S., Sun, X., Xu, X., Fernandez, J. A., Griffin, J. H., Evatt, B. Activated protein C resistance caused by Arg506Gln mutation in factor Va Lancet  1994 343:1361-1362  DOI:10.1016/s0140-6736(94)92497-x  PMID:7910348