Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues

Academic Article
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publication date

  • January 2000

abstract

  • Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretagogue affinity of a screening lead 4.