Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Rodriguez-Gabriel, M. A.
  • Burns, G.
  • McDonald, W. H.
  • Martin, V.
  • Yates III, John
  • Bahler, J.
  • Russell, Paul

publication date

  • December 2003

journal

  • EMBO Journal  Journal

abstract

  • Fission yeast Spc1 (Sty1), a stress-activated mitogen-activated protein kinase (MAPK) homologous to human p38, orchestrates global changes in gene expression in response to diverse forms of cytotoxic stress. This control is partly mediated through Atf1, a transcription factor homologous to human ATF2. How Spc1 controls Atf1, and how the cells tailor gene expression patterns to different forms of stress, are unknown. Here we describe Csx1, a novel protein crucial for survival of oxidative but not osmotic stress. Csx1 associates with and stabilizes atf1+ mRNA in response to oxidative stress. Csx1 controls expression of the majority of the genes induced by oxidative stress, including most of the genes regulated by Spc1 and Atf1. These studies reveal a novel mechanism controlling MAPK-regulated transcription factors and suggest how gene expression patterns can be customized to specific forms of stress. Csx1-like proteins in humans may perform similar tasks.

subject areas

  • Fungal Proteins
  • Gene Expression Regulation
  • Homeodomain Proteins
  • Mutagenesis, Insertional
  • Oligonucleotide Array Sequence Analysis
  • Oxidative Stress
  • Phosphorylation
  • RNA, Messenger
  • RNA-Binding Proteins
  • Recombinant Proteins
  • Schizosaccharomyces
  • Transcription Factors
scroll to property group menus

Research

keywords

  • RNA-binding protein
  • Schizosaccharomyces pombe
  • microarray
  • oxidative stress
  • post-transcriptional control of gene expression
scroll to property group menus

Identity

PubMed Central ID

  • PMC291838

International Standard Serial Number (ISSN)

  • 0261-4189

Digital Object Identifier (DOI)

  • 10.1093/emboj/cdg597

PubMed ID

  • 14633985
scroll to property group menus

Additional Document Info

start page

  • 6256

end page

  • 6266

volume

  • 22

issue

  • 23

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support