Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

A phage display system with unnatural amino acids

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Feng, T.
  • Tsao, M. L.
  • Schultz, Peter

publication date

  • December 2004

journal

  • Journal of the American Chemical Society  Journal

abstract

  • We report a general method to display peptide-containing unnatural amino acids on filamentous M13 phage. Five distinct unnatural amino acids were site-specifically incorporated at the N-terminal of the M13 phage minor coat protein pIII. Phages that contain p-azidophenylalanine can undergo a highly specific azide-alkyne [3 + 2] cycloaddition reaction with an alkyne-derivatized fluorophore. The generalization of phage display to include unnatural amino acids should significantly increase the scope of phage display technology.

subject areas

  • Amino Acids
  • Capsid Proteins
  • Carrier Proteins
  • DNA-Binding Proteins
  • Methanococcus
  • Peptide Biosynthesis
  • Peptide Library
  • Viral Fusion Proteins
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja045673m

PubMed ID

  • 15584720
scroll to property group menus

Additional Document Info

start page

  • 15962

end page

  • 15963

volume

  • 126

issue

  • 49

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support