Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Montane-Jaime, K.
  • Moore, S.
  • Shafe, S.
  • Joseph, R.
  • CrookSa, H.
  • Carr, L.
  • Ehlers, Cindy

publication date

  • June 2006

journal

  • Alcohol  Journal

abstract

  • Variants in alcohol dehydrogenase (ADH) genes differ between ethnic groups and have, in some studies, been found to be associated with alcohol dependence and alcoholic liver disease. This study sought to determine whether an association exists between ADH (ADH1C previously ADH3, ADH1B*2 previously ADH2*2) genotypes, alcohol dependence, drinking history, and liver function tests in the two major ethnic groups of Trinidad and Tobago (TT). One hundred and forty-five alcohol-dependent individuals of both East Indian (Indo-TT) and African (Afro-TT) ancestry, and 108 controls matched by age, sex, and education participated in the study. Serum levels of alanine and aspartate aminotransferase (ALT, AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and gamma-glutamyltransferase (GGT) as well as presence of HIV, hepatitis B surface antigen, and anti-hepatitis C virus antibody were determined. There was a significant difference in the distribution of ADH1C allele polymorphisms between the ethnic groups (P<.0001). Forty-three percent of the Indo-TT were found to have one ADH1C*2 allele and 5% were homozygous, whereas, only 23% of Afro-TT had one allele and one was homozygous. Only three individuals had an ADH1B*2 allele (one Indo-TT alcohol dependent, two Indo-TT controls). The ADH1C*2 allele was significantly associated with alcohol dependence overall and within Indo-TT ancestry, however, it was not associated with current or heaviest alcohol consumption levels. Individuals with at least one ADH1C*2 allele also had significantly elevated levels of ALP (P<.02) and GGT (P<.02) as compared to individuals homozygous for ADH1C*. Additionally, GGT levels were also found to be elevated (P<.02) within Indo-TT alcohol dependents with at least one ADH1C*2 allele but not within the Afro-TT alcohol dependents with that allele. A linear regression that included alcohol dependence and levels of alcohol consumption confirmed that levels of serum GGT were significantly associated with the ADH1C*2 genotype. These results suggest that ADH1C polymorphisms are associated with alcohol dependence and alcohol associated elevations of liver enzymes in a population with a low frequency of ADH1B2 alleles.

subject areas

  • Adult
  • African Continental Ancestry Group
  • Alanine Transaminase
  • Alcohol Dehydrogenase
  • Alcohol Drinking
  • Alcoholism
  • Alkaline Phosphatase
  • Aspartate Aminotransferases
  • Ethnic Groups
  • Female
  • Humans
  • L-Lactate Dehydrogenase
  • Liver
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Trinidad and Tobago
  • gamma-Glutamyltransferase
scroll to property group menus

Research

keywords

  • ADHIB
  • ADHIC
  • Trinidad and Tobago
  • alcohol dependence
  • liver enzymes
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0741-8329

Digital Object Identifier (DOI)

  • 10.1016/j.alcohol.2006.08.002

PubMed ID

  • 17134660
scroll to property group menus

Additional Document Info

start page

  • 81

end page

  • 86

volume

  • 39

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support