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On the use of combinatorial antibody libraries to clone the fossil record of an individuals immune-response

Academic Article
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Overview

authors

  • Lerner, Richard
  • Barbas III, Carlos
  • Kang, A. S.
  • Burton, Dennis

publication date

  • November 1991

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • For about the last century the record of immunological events could only be obtained from serum proteins. We suggest that in the future this will change and the far more detailed nucleic acid record will provide new insights into immunological processes as well as selective access to the complete repertoire.

subject areas

  • Antibodies
  • Bone Marrow Cells
  • Cloning, Molecular
  • Gene Library
  • Humans
  • Immunologic Memory
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Research

keywords

  • AIDS
  • CATALYTIC ANTIBODIES
  • IMMUNOLOGICAL MEMORY
  • PASSIVE ANTIBODY
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.88.21.9705

PubMed ID

  • 1946391
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Additional Document Info

start page

  • 9705

end page

  • 9706

volume

  • 88

issue

  • 21

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