related to degree

• Soenen, Danielle, Ph.D. in Chemistry, Scripps Research 1998 - 2003

authors

• Soenen, Danielle
• Hwang, I.
• Hedrick, M. P.
• Boger, Dale

publication date

• 2003

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

abstract

• Key analogue derivatives of the ningalins, potent multidrug resistance (MDR) reversal compounds, were examined resulting in the discovery of a potent MDR reversal agent that hypersensitizes P-gp resistant tumor cell lines to front-line conventional therapeutic agents.

subject areas

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Antineoplastic Agents
• Cell Line, Tumor
• Cell Survival
• Doxorubicin
• Drug Resistance, Multiple
• Drug Resistance, Neoplasm
• Heterocyclic Compounds, 3-Ring
• Humans
• Structure-Activity Relationship
• Vinblastine

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/s0960-894x(03)00294-4

PubMed ID

• 12729663

start page

• 1777

end page

• 1781

volume

• 13

issue

• 10