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Multidrug resistance reversal activity of key ningalin analogues

Academic Article
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Overview

related to degree

  • Soenen, Danielle, Ph.D. in Chemistry, Scripps Research 1998 - 2003

authors

  • Soenen, Danielle
  • Hwang, I.
  • Hedrick, M. P.
  • Boger, Dale

publication date

  • 2003

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • Key analogue derivatives of the ningalins, potent multidrug resistance (MDR) reversal compounds, were examined resulting in the discovery of a potent MDR reversal agent that hypersensitizes P-gp resistant tumor cell lines to front-line conventional therapeutic agents.

subject areas

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Cell Line, Tumor
  • Cell Survival
  • Doxorubicin
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Heterocyclic Compounds, 3-Ring
  • Humans
  • Structure-Activity Relationship
  • Vinblastine
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(03)00294-4

PubMed ID

  • 12729663
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Additional Document Info

start page

  • 1777

end page

  • 1781

volume

  • 13

issue

  • 10

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