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Ligands in crystal structures that aid in functional characterization

Academic Article
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Overview

authors

  • Speers, Anna
  • Cravatt, Benjamin

publication date

  • October 2010

journal

  • Acta Crystallographica Section F-Structural Biology and Crystallization Communications  Journal

abstract

  • Liganded structures can be instrumental in assigning function to uncharacterized proteins by revealing active sites, conserved residues, binding motifs, and substrate specificity. This introduction provides an overview and commentary on the value of liganded structures emerging from the JCSG structural genomics initiative.

subject areas

  • Crystallography, X-Ray
  • Genomics
  • Ligands
  • Models, Molecular
  • Protein Structure, Tertiary
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Identity

PubMed Central ID

  • PMC2954220

International Standard Serial Number (ISSN)

  • 1744-3091

Digital Object Identifier (DOI)

  • 10.1107/s1744309110035748

PubMed ID

  • 20944226
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Additional Document Info

start page

  • 1306

end page

  • 1308

volume

  • 66

issue

  • Pt 10

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