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Effects of chloride ion substitution on the frequency dependence and α-autoinhibition of [3H]noradrenaline secretion in guinea-pig vas deferens

Academic Article
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Overview

authors

  • Stjarne, L.
  • Alberts, P.
  • Bartfai, Tamas

publication date

  • July 1986

journal

  • Acta Physiologica Scandinavica  Journal

abstract

  • Guinea-pig isolated vas deferens, in which the stores of noradrenaline (NA) had been labelled by preincubation with [3H]NA, was used to study the effects of substitution of chloride with other anions, on transmitter secretion evoked by electrical stimulation of postganglionic sympathetic nerves. Chloride was omitted from the Tyrode's solution and substituted with acetate, nitrate, methylsulphate, sulphate or HEPES. All substituents increased both the spontaneous and the stimulus-evoked fractional secretion of [3H]NA under control conditions. The effect was essentially the same at all frequencies of stimulation (1-8 Hz). In the presence of the alpha-adrenoceptor blocker phentolamine, which enhanced the secretion of [3H]NA in all media, the secretion was not further enhanced by chloride substitution. Chloride substitution reduced the depressing effect of exogenous NA on the secretory response. In conclusion, chloride ions may be required for full expression of alpha-adrenoceptor-mediated inhibition of [3H]NA secretion, but do not markedly influence facilitation by increased frequency of stimulation.

subject areas

  • Animals
  • Chlorides
  • Culture Media
  • Electric Stimulation
  • Guinea Pigs
  • In Vitro Techniques
  • Male
  • Norepinephrine
  • Phentolamine
  • Receptors, Adrenergic, alpha
  • Sympathetic Nervous System
  • Vas Deferens
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Identity

International Standard Serial Number (ISSN)

  • 0001-6772

Digital Object Identifier (DOI)

  • 10.1111/j.1748-1716.1986.tb07912.x

PubMed ID

  • 3019083
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Additional Document Info

start page

  • 327

end page

  • 333

volume

  • 127

issue

  • 3

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