recent publications
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academic article
- Tsunoda, K., Ota, T., Saito, M., Hata, T., Shimizu, A., Ishiko, A., Yamada, T., Nakagawa, T., Kowalczyk, A. P., Amagai, M. Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris American Journal of Pathology 2011 179:795-806 DOI:10.1016/j.ajpath.2011.04.015 PMID:21718682 PMCID:PMC3157249
- Ota, T., Aoki-Ota, M., Tsunoda, K., Nishikawa, T., Koyasu, S., Amagai, M. Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance International Immunology 2008 20:1351-1360 DOI:10.1093/intimm/dxn095 PMID:18765425
- Aoki-Ota, M., Kinoshita, M., Ota, T., Tsunoda, K., Iwasaki, T., Tanaka, S., Koyasu, S., Nishikawa, T., Amagai, M. Tolerance induction by the blockade of CD40/CD154 interaction in pemphigus vulgaris mouse model Journal of Investigative Dermatology 2006 126:105-113 DOI:10.1038/sj.jid.5700016 PMID:16417225
- Shimizu, A., Ishiko, A., Ota, T., Saito, H., Oka, H., Tsunoda, K., Amagai, M., Nishikawa, T. In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line Journal of Investigative Dermatology 2005 124:984-989 DOI:10.1111/j.0022-202X.2005.23706.x PMID:15854040
- Ota, T., Aoki-Ota, M., Tsunoda, K., Simoda, K., Nishikawa, T., Amagai, M., Koyasu, S. Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism International Immunology 2004 16:1487-1495 DOI:10.1093/intimm/dxh150 PMID:15339881
- Aoki-Ota, M., Tsunoda, K., Ota, T., Iwasaki, T., Koyasu, S., Amagai, M., Nishikawa, T. A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice British Journal of Dermatology 2004 151:346-354 DOI:10.1111/j.1365-2133.2004.06056.x PMID:15327541
- Shimizu, A., Ishiko, A., Ota, T., Tsunoda, K., Amagai, M., Nishikawa, T. IgG binds to desmoglein 3 in desmosomes and causes a desmosomal split without keratin retraction in a pemphigus mouse model Journal of Investigative Dermatology 2004 122:1145-1153 DOI:10.1111/j.0022-202X.2004.22426.x PMID:15140217
- Ohyama, M., Ota, T., Aoki, M., Tsunoda, K., Harada, R., Koyasu, S., Nishikawa, T., Amagai, M. Suppression of the immune response against exogenous desmoglein 3 in desmoglein 3 knockout mice: an implication for gene therapy Journal of Investigative Dermatology 2003 120:610-615 DOI:10.1046/j.1523-1747.2003.12090.x PMID:12648224
- Tsunoda, K., Ota, T., Aoki, M., Yamada, T., Nagai, T., Nakagawa, T., Koyasu, S., Nishikawa, T., Amagai, M. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3 Journal of Immunology 2003 170:2170-2178 PMID:12574390
- Shimizu, A., Ishiko, A., Ota, T., Tsunoda, K., Koyasu, S., Amagai, M., Nishikawa, T. Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris Archives of Dermatological Research 2002 294:318-323 DOI:10.1007/s00403-002-0341-z PMID:12373337
- Tsunoda, K., Ota, T., Suzuki, H., Ohyama, M., Nagai, T., Nishikawa, T., Amagai, M., Koyasu, S. Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris European Journal of Immunology 2002 32:627-633 DOI:10.1002/1521-4141(200203)32:3<627::aid-immu627>3.0.co;2-1 PMID:11857336
- Ohyama, M., Amagai, M., Tsunoda, K., Ota, T., Koyasu, S., Hata, J., Umezawa, A., Nishikawa, T. Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris Journal of Investigative Dermatology 2002 118:199-204 DOI:10.1046/j.0022-202x.2001.01643.x PMID:11851895