recent publications

• academic article

  • Boger, D. L., Miyauchi, H., Du, W., Hardouin, C., Fecik, R. A., Cheng, H., Hwang, I., Hedrick, M. P., Leung, D., Acevedo, O., Guimaraes, C. R. W., Jorgensen, W. L., et al. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics Journal of Medicinal Chemistry  2005 48:1849-1856  DOI:10.1021/jm049614v  PMID:15771430  PMCID:PMC2492884
  • Boger, D. L., Miyauchi, H., Hedrick, M. P. Alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution Bioorganic & Medicinal Chemistry Letters  2001 11:1517-1520  DOI:10.1016/s0960-894x(01)00211-6  PMID:11412972
  • Boger, D. L., Sato, H., Lerner, A. E., Hedrick, M. P., Fecik, R. A., Miyauchi, H., Wilkie, G. D., Austin, B. J., Patricelli, M. P., Cravatt, B. F. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide Proceedings of the National Academy of Sciences of the United States of America  2000 97:5044-5049  DOI:10.1073/pnas.97.10.5044  PMID:10805767  PMCID:PMC25778
  • Boger, D. L., Fecik, R. A., Patterson, J. E., Miyauchi, H., Patricelli, M. P., Cravatt, B. F. Fatty acid amide hydrolase substrate specificity Bioorganic & Medicinal Chemistry Letters  2000 10:2613-2616  DOI:10.1016/s0960-894x(00)00528-x  PMID:11128635