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Apoptosis induced by HIV infection in H9 T cells is blocked by ICE-family protease inhibition but not by a Fas(CD95) antagonist

Academic Article
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Overview

authors

  • Glynn, J. M.
  • McElligott, D. L.
  • Mosier, Donald

publication date

  • October 1996

journal

  • Journal of Immunology  Journal

abstract

  • Infection of human CD4-positive T lymphocytes by human immunodeficiency virus type 1 (HIV-1) is thought to lead to death of infected cells by apoptosis, although one recent report questions this conclusion. Here we demonstrate that HIV-1-induced apoptosis of the H9 human T cell line is blocked by peptide inhibitors of IL-1 beta converting enzyme (ICE)-family proteases, but not by the antagonistic M3 anti-Fas Ab. Apoptosis occurred in all phases of the cell cycle, not selectively in G2 as a consequence of vpr-mediated cell cycle arrest. We conclude that apoptosis accounts for all cell death related to HIV-1 infection of the human CD4-positive cell line H9, requires an ICE-like protease but is not Fas mediated, and occurs in all phases of the cell cycle.

subject areas

  • Amino Acid Chloromethyl Ketones
  • Amino Acid Sequence
  • Antibodies, Monoclonal
  • Antigens, CD95
  • Apoptosis
  • Caspase 1
  • Cell Cycle
  • Cell Line
  • Cysteine Endopeptidases
  • HIV Infections
  • Humans
  • Molecular Sequence Data
  • Protease Inhibitors
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 8816376
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Additional Document Info

start page

  • 2754

end page

  • 2758

volume

  • 157

issue

  • 7

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