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Chemoenzymatic approaches to glycoprotein synthesis

Academic Article
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Overview

authors

  • Bennett, C. S.
  • Wong, Chi-Huey

publication date

  • 2007

journal

  • Chemical Society Reviews  Journal

abstract

  • The construction of homogeneous glycoproteins presents a formidable challenge to the synthetic chemist. Over the past few years there has been an explosion in the number of methods developed to address this problem. These methods include the development of novel ligation technologies for the synthesis of the protein backbone, as well chemical and enzymatic approaches for introducing complex glycans into the peptide backbone. This tutorial review discusses the application of these techniques to the synthesis of peptides and proteins possessing well defined glycans.

subject areas

  • Enzymes
  • Glycoproteins
  • Proteins
  • RNA, Transfer
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Identity

International Standard Serial Number (ISSN)

  • 0306-0012

Digital Object Identifier (DOI)

  • 10.1039/b617709c

PubMed ID

  • 17619683
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Additional Document Info

start page

  • 1227

end page

  • 1238

volume

  • 36

issue

  • 8

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