recent publications

• academic article

  • Duong, B. H., Ota, T., Aoki-Ota, M., Cooper, A. B., Ait-Azzouzene, D., Vela, J. L., Gavin, A. L., Nemazee, D. Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape Journal of Immunology  2011 187:5596-5605  DOI:10.4049/jimmunol.1102479  PMID:22043016  PMCID:PMC3227399
  • Ait-Azzouzene, D., Kono, D. H., Gonzalez-Quintial, R., McHeyzer-Williams, L. J., Lim, M., Wickramarachchi, D., Gerdes, T., Gavin, A. L., Skog, P., McHeyzer-Williams, M. G., Nemazee, D., Theofilopoulos, A. N. Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice Journal of Immunology  2010 185:1015-1027  DOI:10.4049/jimmunol.1000698  PMID:20554953  PMCID:PMC3641794
  • Duong, B. H., Ota, T., Ait-Azzouzene, D., Aoki-Ota, M., Vela, J. L., Huber, C., Walsh, K., Gavin, A. L., Nemazee, D. Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen Journal of Immunology  2010 184:4143-4158  DOI:10.4049/jimmunol.0903564  PMID:20231687  PMCID:PMC2874719
  • Verkoczy, L., Duong, B., Skog, P., Ait-Azzouzene, D., Puri, K., Vela, J. L., Nemazee, D. Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off rags and promotes B cell-positive selection Journal of Immunology  2007 178:6332-6341  PMID:17475862  PMCID:PMC3777394
  • Ait-Azzouzene, D., Gavin, A. L., Skog, P., Duong, B., Nemazee, D. Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of IgK-reactive macroself antigen European Journal of Immunology  2006 36:985-996  DOI:10.1002/eji.2005355811  PMID:16511898
  • Watson, L. C., Moffatt-Blue, C. S., McDonald, R. Z., Kompfner, E., Ait-Azzouzene, D., Nemazee, D., Theofilopoulos, A. N., Kono, D. H., Feeney, A. J. Paucity of V-D-D-J rearrangements and V-H replacement events in lupus prone and nonautoimmune TdT(-/-) and TdT(+/+) mice Journal of Immunology  2006 177:1120-1128  PMID:16818769
  • Ait-Azzouzene, D., Verkoczy, L., Duong, B., Skog, P., Gavin, A. L., Nemazee, D. Split tolerance in peripheral B cell subsets in mice expressing a low level of Ig kappa-reactive ligand Journal of Immunology  2006 176:939-948  PMID:16393979
  • Verkoczy, L., Ait-Azzouzene, D., Skog, P., Martensson, A., Lang, J., Duong, B., Nemazee, D. A role for nuclear factor kappa b/rel transcription factors in the regulation of the recombinase activator genes Immunity  2005 22:519-531  DOI:10.1016/j.immuni.2005.03.006  PMID:15845455  PMCID:PMC3792720
  • Ait-Azzouzene, D., Verkoczy, L., Peters, J., Gavin, A., Skog, P., Vela, J. L., Nemazee, D. An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system Journal of Experimental Medicine  2005 201:817-828  DOI:10.1084/jem.20041854  PMID:15738053  PMCID:PMC2212821
  • Gavin, A. L., Duong, B., Skog, P., Ait-Azzouzene, D., Greaves, D. R., Scott, M. L., Nemazee, D. delta BAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models Journal of Immunology  2005 175:319-328  PMID:15972664
  • Ait-Azzouzene, D., Skog, P., Retter, M., Kouskoff, V., Hertz, M., Lang, J., Kench, J., Chumley, M., Melamed, D., Sudaria, J., Gavin, A., Martensson, A., et al. Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection Immunological Reviews  2004 197:219-230  DOI:10.1111/j.0105-2896.2004.0106.x  PMID:14962198
  • Gavin, A. L., Ait-Azzouzene, D., Ware, C. F., Nemazee, D. delta BAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF Journal of Biological Chemistry  2003 278:38220-38228  DOI:10.1074/jbc.M306852200  PMID:12867412  PMCID:PMC3792716
  • Ait-Azzouzene, D., Gendron, M. C., Houdayer, M., Langkopf, A., Burki, K., Nemazee, D., Kanellopoulos-Langevin, C. Maternal b lymphocytes specific for paternal histocompatibility antigens are partially deleted during pregnancy Journal of Immunology  1998 161:2677-2683  PMID:9743323