recent publications

• academic article

  • Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., et al. ENU-induced phenovariance in mice: Inferences from 587 mutations BMC Research Notes  2012 5:577  DOI:10.1186/1756-0500-5-577  PMID:23095377  PMCID:PMC3532239
  • Blasius, A. L., Arnold, C. N., Georgel, P., Rutschmann, S., Xia, Y., Lin, P., Ross, C., Li, X. H., Smart, N. G., Beutler, B. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells Proceedings of the National Academy of Sciences of the United States of America  2010 107:19973-19978  DOI:10.1073/pnas.1014051107  PMID:21045126  PMCID:PMC2993408
  • Georgel, P., Du, X., Hoebe, K., Beutler, B. ENU mutagenesis in mice Methods in Molecular Biology  2008 415:1-16  DOI:10.1007/978-1-59745-570-1_1  PMID:18370145
  • Otsuka, M., Jing, Q., Georgel, P., New, L., Chen, J. M., Mols, J., Kang, Y. J., Jiang, Z. F., Du, X., Cook, R., Das, S. C., Pattnaik, A. K., et al. Hypersusceptibility to vesicular stomatitis virus infection in dicer1-deficient mice is due to impaired mir24 and mir93 expression Immunity  2007 27:123-134  DOI:10.1016/j.immuni.2007.05.014  PMID:17613256
  • Georgel, P., Jiang, Z. F., Kunz, S., Janssen, E., Mols, J., Hoebe, K., Bahram, S., Oldstone, M. B. A., Beutler, B. Vesicular stomatitis virus glycoprotein g activates a specific antiviral toll-like receptor 4-dependent pathway Virology  2007 362:304-313  DOI:10.1016/j.virol.2006.12.032  PMID:17292937
  • Jiang, Z. F., Georgel, P., Li, C. L., Choe, J., Crozat, K., Rutschmann, S., Du, X., Bigby, T., Mudd, S., Sovath, S., Wilson, I. A., Olson, A. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis Proceedings of the National Academy of Sciences of the United States of America  2006 103:10961-10966  DOI:10.1073/pnas.0603804103  PMID:16832055  PMCID:PMC1544157
  • Crozat, K., Georgel, P., Rutschmann, S., Mann, N., Du, X., Hoebe, K., Beutler, B. Analysis of the MCMV resistome by ENU mutagenesis Mammalian Genome  2006 17:398-406  DOI:10.1007/s00335-005-0164-2  PMID:16688530
  • Huber, M., Kalis, C., Keck, S., Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Beutler, B., Galanos, C., Freudenberg, M. A. R-form lps, the master key to the activation of tlr4/md-2-positive cells European Journal of Immunology  2006 36:701-711  DOI:10.1002/eji.200535593  PMID:16506285
  • Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A. A., et al. The unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9 Nature Immunology  2006 7:156-164  DOI:10.1038/ni1297  PMID:16415873
  • Beutler, B., Jiang, Z. F., Georgel, P., Crozat, K., Croker, B., Rutschmann, S., Du, X., Hoebe, K. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large Annual Review of Immunology  2006 24:353-389  DOI:10.1146/annurev.immunol.24.021605.090552  PMID:16551253
  • Hoebe, K., Jiang, Z., Georgel, P., Tabeta, K., Janssen, E., Du, X., Beutler, B. TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy Current Pharmaceutical Design  2006 12:4123-4134  DOI:10.2174/138161206778743466  PMID:17100615
  • Georgel, P., Crozat, K., Lauth, X., Makrantonaki, E., Seltmann, H., Sovath, S., Hoebe, K., Du, X., Rutschmann, S., Jiang, Z. F., Bigby, T., Nizet, V., et al. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria Infection and Immunity  2005 73:4512-4521  DOI:10.1128/iai.73.8.4512-4521.2005  PMID:16040962
  • Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., Freudenberg, M., Beutler, B. Cd14 is required for myd88-independent lps signaling Nature Immunology  2005 6:565-570  DOI:10.1038/ni1207  PMID:15895089
  • Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zahringer, U., Beutler, B. Cd36 is a sensor of diacylglycerides Nature  2005 433:523-527  DOI:10.1038/nature03253  PMID:15690042
  • Beutler, B., Crozat, K., Koziol, J. A., Georgel, P. Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model Current Opinion in Immunology  2005 17:36-43  DOI:10.1016/j.coi.2004.11.004  PMID:15653308
  • Beutler, B., Hoebe, K., Georgel, P., Tabeta, K., Du, X. Genetic analysis of innate immunity: Identification and function of the tir adapter proteins Advances in Experimental Medicine and Biology  2005 560:29-39  DOI:10.1007/0-387-24180-9_4  PMID:15934170
  • Beutler, B., Georgel, P., Rutschmann, S., Jiang, Z., Croker, B., Crozat, K. Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV) Briefings in Functional Genomics & Proteomics  2005 4:203-213  DOI:10.1093/bfgp/4.3.203  PMID:16420746
  • Beutler, B., Hoebe, K., Georgel, P., Tabeta, K., Du, X. Genetic analysis of innate immunity: Tir adapter proteins in innate and adaptive immune responses Microbes and Infection  2004 6:1374-1381  DOI:10.1016/j.micinf.2004.08.017  PMID:15596123
  • Anfossi, N., Robbins, S. H., Ugolini, S., Georgel, P., Hoebe, K., Bouneaud, C., Ronet, C., Kaser, A., DiCioccio, C. B., Tomasello, E., Blumberg, R. S., Beutler, B., et al. Expansion and function of CD8(+) T cells, expressing Ly49 inhibitory receptors specific for MHC class I molecules Journal of Immunology  2004 173:3773-3782  PMID:15356124
  • Tabeta, K., Georgel, P., Janssen, E., Du, X., Hoebe, K., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., Alexopoulou, L., Flavell, R. A., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Proceedings of the National Academy of Sciences of the United States of America  2004 101:3516-3521  DOI:10.1073/pnas.0400525101  PMID:14993594  PMCID:PMC373494
  • Beutler, B., Hoebe, K., Du, X., Janssen, E., Georgel, P., Tabeta, K. Lps2 and signal transduction in sepsis: At the intersection of host responses to bacteria and viruses Scandinavian Journal of Infectious Diseases  2003 35:563-567  DOI:10.1080/00365540310016295  PMID:14620135
  • Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., et al. Identification of lps2 as a key transducer of myd88-independent tir signalling Nature  2003 424:743-748  DOI:10.1038/nature01889  PMID:12872135