recent publications

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  • Shibata, A., Moiani, D., Arvai, A. S., Perry, J., Harding, S. M., Genois, M. M., Maity, R., van Rossum-Fikkert, S., Kertokalio, A., Romoli, F., Ismail, A., Ismalaj, E., et al. DNA double-strand break repair pathway choice Is directed by distinct MRE11 nuclease activities Molecular Cell  2014 53:7-18  DOI:10.1016/j.molcel.2013.11.003  PMID:24316220  PMCID:PMC3909494
  • Groocock, L. M., Nie, M., Prudden, J., Moiani, D., Wang, T., Cheltsov, A., Rambo, R. P., Arvai, A. S., Hitomi, C., Tainer, J. A., Luger, K., Perry, J. J. P., et al. RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response EMBO Reports  2014 15:601-608  DOI:10.1002/embr.201338369  PMID:24714598  PMCID:PMC4210088
  • Tsutakawa, S. E., Shin, D. S., Mol, C. D., Izumi, T., Arvai, A. S., Mantha, A. K., Szczesny, B., Ivanov, I. N., Hosfield, D. J., Maiti, B., Pique, M. E., Frankel, K. A., et al. Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes Journal of Biological Chemistry  2013 288:8445-8455  DOI:10.1074/jbc.M112.422774  PMID:23355472  PMCID:PMC3605660
  • Latypov, V. F., Tubbs, J. L., Watson, A. J., Marriott, A. S., McGown, G., Thorncroft, M., Wilkinson, O. J., Senthong, P., Butt, A., Arvai, A. S., Millington, C. L., Povey, A. C., et al. Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines Molecular Cell  2012 47:50-60  DOI:10.1016/j.molcel.2012.04.028  PMID:22658721  PMCID:PMC3398191
  • Hitomi, K., Arvai, A. S., Yamamoto, J., Hitomi, C., Teranishi, M., Hirouchi, T., Yamamoto, K., Iwai, S., Tainer, J. A., Hidema, J., Getzoff, E. D. Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants Journal of Biological Chemistry  2012 287:12060-12069  DOI:10.1074/jbc.M111.244020  PMID:22170053  PMCID:PMC3320952
  • Christie, J. M., Arvai, A. S., Baxter, K. J., Heilmann, M., Pratt, A. J., O'Hara, A., Kelly, S. M., Hothorn, M., Smith, B. O., Hitomi, K., Jenkins, G. I., Getzoff, E. D. Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges Science  2012 335:1492-1496  DOI:10.1126/science.1218091  PMID:22323738  PMCID:PMC3505452
  • Christie, J. M., Hitomi, K., Arvai, A. S., Hartfield, K. A., Mettlen, M., Pratt, A. J., Tainer, J. A., Getzoff, E. D. Structural tuning of the fluorescent protein iLOV for improved photostability Journal of Biological Chemistry  2012 287:22295-22304  DOI:10.1074/jbc.M111.318881  PMID:22573334  PMCID:PMC3381190
  • Williams, G. J., Williams, R. S., Williams, J. S., Moncalian, G., Arvai, A. S., Limbo, O., Guenther, G., SilDas, S., Hammel, M., Russell, P., Tainer, J. A. ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Nature Structural & Molecular Biology  2011 18:423-431  DOI:10.1038/nsmb.2038  PMID:21441914  PMCID:PMC3118400
  • Prudden, J., Perry, J. J. P., Nie, M. H., Vashisht, A. A., Arvai, A. S., Hitomi, C., Guenther, G., Wohlschlegel, J. A., Tainer, J. A., Boddy, M. N. DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes Molecular and Cellular Biology  2011 31:2299-2310  DOI:10.1128/mcb.05188-11  PMID:21444718  PMCID:PMC3133251
  • Tsutakawa, S. E., Classen, S., Chapados, B. R., Arvai, A. S., Finger, L. D., Guenther, G., Tomlinson, C. G., Thompson, P., Sarker, A. H., Shen, B. H., Cooper, P. K., Grasby, J. A., et al. Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the fen1 superfamily Cell  2011 145:198-211  DOI:10.1016/j.cell.2011.03.004  PMID:21496641  PMCID:PMC3086263
  • Hartung, S., Arvai, A. S., Wood, T., Kolappan, S., Shin, D. S., Craig, L., Tainer, J. A. Ultrahigh resolution and full-length pilin structures with insights for filament assembly, pathogenic functions, and vaccine potential Journal of Biological Chemistry  2011 286:44254-44265  DOI:10.1074/jbc.M111.297242  PMID:22027840  PMCID:PMC3243539
  • Rosenfeld, R. J., Bonaventura, J., Szymczyna, B. R., MacCoss, M. J., Arvai, A. S., Yates, J. R., Tainer, J. A., Getzoff, E. D. Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation Journal of Biological Chemistry  2010 285:31581-31589  DOI:10.1074/jbc.M109.072496  PMID:20659888  PMCID:PMC2951232
  • Lim, M. S., Ng, D., Zong, Z. S., Arvai, A. S., Taylor, R. K., Tainer, J. A., Craig, L. Vibrio cholerae el tor tcpa crystal structure and mechanism for pilus-mediated microcolony formation Molecular Microbiology  2010 77:755-770  DOI:10.1111/j.1365-2958.2010.07244.x  PMID:20545841  PMCID:PMC2939829
  • Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., et al. Flipping of alkylated DNA damage bridges base and nucleotide excision repair Nature  2009 459:808-813  DOI:10.1038/nature08076  PMID:19516334  PMCID:PMC2729916
  • Hitomi, K., DiTacchio, L., Arvai, A. S., Yamamoto, J., Kim, S. T., Todo, T., Tainer, J. A., Iwai, S., Panda, S., Getzoff, E. D. Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes Proceedings of the National Academy of Sciences of the United States of America  2009 106:6962-6967  DOI:10.1073/pnas.0809180106  PMID:19359474  PMCID:PMC2678464
  • Prudden, J., Perry, J. J. P., Arvai, A. S., Tainer, J. A., Boddy, M. N. Molecular mimicry of SUMO promotes DNA repair Nature Structural & Molecular Biology  2009 16:509-516  DOI:10.1038/nsmb.1582  PMID:19363481  PMCID:PMC2711901
  • Nishimura, N., Hitomi, K., Arvai, A. S., Rambo, R. P., Hitomi, C., Cutler, S. R., Schroeder, J. I., Getzoff, E. D. Structural mechanism of abscisic acid binding and signaling by dimeric PYR1 Science  2009 326:1373-1379  DOI:10.1126/science.1181829  PMID:19933100  PMCID:PMC2835493
  • Dalhus, B., Arvai, A. S., Rosnes, I., Olsen, O. E., Backe, P. H., Alseth, I., Gao, H. H., Cao, W. G., Tainer, J. A., Bjoras, M. Structures of endonuclease v with DNA reveal initiation of deaminated adenine repair Nature Structural & Molecular Biology  2009 16:138-143  DOI:10.1038/nsmb.1538  PMID:19136958  PMCID:PMC3560532
  • Garcin, E. D., Arvai, A. S., Rosenfeld, R. J., Kroeger, M. D., Crane, B. R., Andersson, G., Andrews, G., Hamley, P. J., Mallinder, P. R., Nicholls, D. J., St-Gallay, S. A., Tinker, A. C., et al. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase Nature Chemical Biology  2008 4:700-707  DOI:10.1038/nchembio.115  PMID:18849972  PMCID:PMC2868503
  • Fan, L., Fuss, J. O., Cheng, Q. J., Arvai, A. S., Hammel, M., Roberts, V. A., Cooper, P. K., Tainer, J. A. Xpd helicase structures and activities: Insights into the cancer and aging phenotypes from xpd mutations Cell  2008 133:789-800  DOI:10.1016/j.cell.2008.04.030  PMID:18510924  PMCID:PMC3055247
  • Fan, L., Arvai, A. S., Cooper, P. K., Iwai, S., Hanaoka, F., Tainer, J. A. Conserved xpb core structure and motifs for DNA unwinding: Implications for pathway selection of transcription or excision repair Molecular Cell  2006 22:27-37  DOI:10.1016/j.molcel.2006.02.017  PMID:16600867
  • Craig, L., Volkmann, N., Arvai, A. S., Pique, M. E., Yeager, M., Egelman, E. H., Tainer, J. A. Type iv pilus structure by cryo-electron microscopy and crystallography: Implications for pilus assembly and functions Molecular Cell  2006 23:651-662  DOI:10.1016/j.molcel.2006.07.004  PMID:16949362
  • Hitomi, K., Oyama, T., Han, S. G., Arvai, A. S., Getzoff, E. D. Tetrameric architecture of the circadian clock protein KaiB - a novel interface for intermolecular interactions and its impact on the circadian rhythm Journal of Biological Chemistry  2005 280:19127-19135  DOI:10.1074/jbc.M411284200  PMID:15716274
  • Manuel, R. C., Hitomi, K., Arvai, A. S., House, P. G., Kurtz, A. J., Dodson, M. L., McCullough, A. K., Tainer, J. A., Lloyd, R. S. Reaction intermediates in the catalytic mechanism of escherichia coli muty DNA glycosylase Journal of Biological Chemistry  2004 279:46930-46939  DOI:10.1074/jbc.M403944200  PMID:15326180
  • Shin, D. S., Pellegrini, L., Daniels, D. S., Yelent, B., Craig, L., Bates, D., Yu, D. S., Shivji, M. K., Hitomi, C., Arvai, A. S., Volkmann, N., Tsuruta, H., et al. Full-length archaeal rad51 structure and mutants: Mechanisms for rad51 assembly and control by brca2 EMBO Journal  2003 22:4566-4576  DOI:10.1093/emboj/cdg429  PMID:12941707  PMCID:PMC202371
  • Aoyagi, M., Arvai, A. S., Tainer, J. A., Getzoff, E. D. Structural basis for endothelial nitric oxide synthase binding to calmodulin EMBO Journal  2003 22:766-775  DOI:10.1093/emboj/cdg078  PMID:12574113  PMCID:PMC145438
  • Wei, C. C., Wang, Z. Q., Arvai, A. S., Hemann, C., Hille, R., Getzoff, E. D., Stuehr, D. J. Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase Biochemistry  2003 42:1969-1977  DOI:10.1021/bi026898h  PMID:12590583
  • Craig, L., Taylor, R. K., Pique, M. E., Adair, B. D., Arvai, A. S., Singh, M., Lloyd, S. J., Shin, D. S., Getzoff, E. D., Yeager, M., Forest, K. T., Tainer, J. A. Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin Molecular Cell  2003 11:1139-1150  DOI:10.1016/s1097-2765(03)00170-9  PMID:12769840
  • Mol, C. D., Arvai, A. S., Begley, T. J., Cunningham, R. P., Tainer, J. A. Structure and activity of a thermostable thymine-DNA glycosylase: Evidence for base twisting to remove mismatched normal DNA bases Journal of Molecular Biology  2002 315:373-384  DOI:10.1006/jmbi.2001.5264  PMID:11786018
  • Han, S. I., Arvai, A. S., Clancy, S. B., Tainer, J. A. Crystal structure and novel recognition motif of rho adp-ribosylating c3 exoenzyme from clostridium botulinum: Structural insights for recognition specificity and catalysis Journal of Molecular Biology  2001 305:95-107  DOI:10.1006/jmbi.2000.4292  PMID:11114250
  • Aoyagi, M., Arvai, A. S., Ghosh, S., Stuehr, D. J., Tainer, J. A., Getzoff, E. D. Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457 Biochemistry  2001 40:12826-12832  DOI:10.1021/bi011183k  PMID:11669619
  • Daniels, D. S., Mol, C. D., Arvai, A. S., Kanugula, S., Pegg, A. E., Tainer, J. A. Active and alkylated human agt structures: A novel zinc site, inhibitor and extrahelical base binding EMBO Journal  2000 19:1719-1730  DOI:10.1093/emboj/19.7.1719  PMID:10747039  PMCID:PMC310240
  • Putnam, C. D., Arvai, A. S., Bourne, Y., Tainer, J. A. Active and inhibited human catalase structures: Ligand and nadph binding and catalytic mechanism Journal of Molecular Biology  2000 296:295-309  DOI:10.1006/jmbi.1999.3458  PMID:10656833
  • Bourne, Y., Watson, M. H., Arvai, A. S., Bernstein, S. L., Reed, S. I., Tainer, J. A. Crystal structure and mutational analysis of the saccharomyces cerevisiae cell cycle regulatory protein cks1: Implications for domain swapping, anion binding and protein interactions Structure with Folding & Design  2000 8:841-850  DOI:10.1016/s0969-2126(00)00175-1  PMID:10997903
  • Crane, B. R., Arvai, A. S., Ghosh, S., Getzoff, E. D., Stuehr, D. J., Tainer, J. A. Structures of the N-omega-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins Biochemistry  2000 39:4608-4621  DOI:10.1021/bi992409a  PMID:10769116
  • Crane, B. R., Rosenfeld, R. J., Arvai, A. S., Ghosh, D. K., Ghosh, S., Tainer, J. A., Stuehr, D. J., Getzoff, E. D. N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization EMBO Journal  1999 18:6271-6281  DOI:10.1093/emboj/18.22.6271  PMID:10562539  PMCID:PMC1171690
  • Putnam, C. D., Shroyer, M. J. N., Lundquist, A. J., Mol, C. D., Arvai, A. S., Mosbaugh, D. W., Tainer, J. A. Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with escherichia coli uracil-DNA glycosylase Journal of Molecular Biology  1999 287:331-346  DOI:10.1006/jmbi.1999.2605  PMID:10080896
  • Thayer, M. M., Olender, E. H., Arvai, A. S., Koike, C. K., Canestrelli, I. L., Stewart, J. D., Benkovic, S. J., Getzoff, E. D., Roberts, V. A. Structural basis for amide hydrolysis catalyzed by the 43C9 antibody Journal of Molecular Biology  1999 291:329-345  DOI:10.1006/jmbi.1999.2960  PMID:10438624
  • Crane, B. R., Arvai, A. S., Ghosh, D. K., Wu, C. Q., Getzoff, E. D., Stuehr, D. J., Tainer, J. A. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate Science  1998 279:2121-2126  DOI:10.1126/science.279.5359.2121  PMID:9516116
  • Crane, B. R., Arvai, A. S., Gachhui, R., Wu, C. Q., Ghosh, D. K., Getzoff, E. D., Stuehr, D. J., Tainer, J. A. The structure of nitric oxide synthase oxygenase domain and inhibitor complexes Science  1997 278:425-431  DOI:10.1126/science.278.5337.425  PMID:9334294
  • Watson, M. H., Bourne, Y., Arvai, A. S., Hickey, M. J., Santiago, A., Bernstein, S. L., Tainer, J. A., Reed, S. I. A mutation in the human cyclin-dependent kinase interacting protein, ckshs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly Journal of Molecular Biology  1996 261:646-657  DOI:10.1006/jmbi.1996.0490  PMID:8800213
  • Slupphaug, G., Mol, C. D., Kavli, B., Arvai, A. S., Krokan, H. E., Tainer, J. A. A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA Nature  1996 384:87-92  DOI:10.1038/384087a0  PMID:8900285
  • Kavli, B., Slupphaug, G., Mol, C. D., Arvai, A. S., Petersen, S. B., Tainer, J. A., Krokan, H. E. Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase EMBO Journal  1996 15:3442-3447  PMID:8670846  PMCID:PMC451908
  • Mol, C. D., Arvai, A. S., Slupphaug, G., Kavli, B., Alseth, I., Krokan, H. E., Tainer, J. A. Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis Cell  1995 80:869-878  DOI:10.1016/0092-8674(95)90290-2  PMID:7697717
  • Mol, C. D., Arvai, A. S., Sanderson, R. J., Slupphaug, G., Kavli, B., Krokan, H. E., Mosbaugh, D. W., Tainer, J. A. Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA Cell  1995 82:701-708  DOI:10.1016/0092-8674(95)90467-0  PMID:7671300
  • Bourne, Y., Arvai, A. S., Bernstein, S. L., Watson, M. H., Reed, S. I., Endicott, J. E., Noble, M. E., Johnson, L. N., Tainer, J. A. Crystal-structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch Proceedings of the National Academy of Sciences of the United States of America  1995 92:10232-10236  DOI:10.1073/pnas.92.22.10232  PMID:7479758
  • Arvai, A. S., Bourne, Y., Hickey, M. J., Tainer, J. A. Crystal-structure of the human cell-cycle protein ckshs1 - single-domain fold with similarity to kinase n-lobe domain Journal of Molecular Biology  1995 249:835-842  DOI:10.1006/jmbi.1995.0341  PMID:7791211
  • Arvai, A. S., Bourne, Y., Williams, D., Reed, S. I., Tainer, J. A. Crystallization and preliminary crystallographic study of human ckshs1 - a cell-cycle regulatory protein Proteins-Structure Function and Genetics  1995 21:70-73  DOI:10.1002/prot.340210109  PMID:7716171
  • Parge, H. E., Arvai, A. S., Murtari, D. J., Reed, S. I., Tainer, J. A. Human ckshs2 atomic-structure - a role for its hexameric assembly in cell-cycle control Science  1993 262:387-395  DOI:10.1126/science.8211159  PMID:8211159