recent publications

• academic article

  • Roth, D. M., Hutt, D. M., Tong, J., Bouchecareilh, M., Wang, N., Seeley, T., Dekkers, J. F., Beekman, J. M., Garza, D., Drew, L., Masliah, E., Morimoto, R. I., et al. Modulation of the maladaptive stress response to manage diseases of protein folding PLoS Biology  2014 12  DOI:10.1371/journal.pbio.1001998  PMID:25406061  PMCID:PMC4236052
  • Hutt, D. M., Balch, W. E. Expanding proteostasis by membrane trafficking networks Cold Spring Harbor Perspectives in Biology  2013 5:a013383  DOI:10.1101/cshperspect.a013383  PMID:23426524  PMCID:PMC3685892
  • Coppinger, J. A., Hutt, D. M., Razvi, A., Koulov, A. V., Pankow, S., Yates, J. R., Balch, W. E. A chaperone trap contributes to the onset of cystic fibrosis PLoS One  2012 7:e37682  DOI:10.1371/journal.pone.0037682  PMID:22701530  PMCID:PMC3365120
  • Hutt, D. M., Roth, D. M., Chalfant, M. A., Youker, R. T., Matteson, J., Brodsky, J. L., Balch, W. E. FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability Journal of Biological Chemistry  2012 287:21914-21925  DOI:10.1074/jbc.M112.339788  PMID:22474283  PMCID:PMC3381152
  • Bouchecareilh, M., Hutt, D. M., Szajner, P., Flotte, T. R., Balch, W. E. Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of alpha 1-antitrypsin deficiency Journal of Biological Chemistry  2012 287:38265-78  DOI:10.1074/jbc.M112.404707  PMID:22995909  PMCID:PMC3488095
  • Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Saldanha, S. A., Hodder, P., Tait, B. D., Garza, D., Balch, W. E., Morimoto, R. I. Small-molecule proteostasis regulators for protein conformational diseases Nature Chemical Biology  2012 8:185-196  DOI:10.1038/nchembio.763  PMID:22198733  PMCID:PMC3262058
  • Balch, W. E., Roth, D. M., Hutt, D. M. Emergent properties of proteostasis in managing cystic fibrosis Cold Spring Harbor Perspectives in Biology  2011 3:a004499  DOI:10.1101/cshperspect.a004499  PMID:21421917  PMCID:PMC3039536
  • Hutt, D. M., Olsen, C. A., Vickers, C. J., Herman, D., Chalfant, M. A., Montero, A., Leman, L. J., Burkle, R., Maryanoff, B. E., Balch, W. E., Ghadiri, M. R. Potential agents for treating cystic fibrosis: cyclic tetrapeptides that restore trafficking and activity of delta F508-CFTR ACS Medicinal Chemistry Letters  2011 2:703-707  DOI:10.1021/ml200136e  PMID:21984958  PMCID:PMC3187562
  • Hutt, D. M., Herman, D., Rodrigues, A. P. C., Noel, S., Pilewski, J. M., Matteson, J., Hoch, B., Kellner, W., Kelly, J. W., Schmidt, A., Thomas, P. J., Matsumura, Y., et al. Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis Nature Chemical Biology  2010 6:25-33  DOI:10.1038/nchembio.275  PMID:19966789  PMCID:PMC2901172
  • Hutt, D. M., Powers, E. T., Balch, W. E. The proteostasis boundary in misfolding diseases of membrane traffic FEBS Letters  2009 583:2639-2646  DOI:10.1016/j.febslet.2009.07.014  PMID:19708088  PMCID:PMC2805282
  • Wang, X. D., Venable, J., LaPointe, P., Hutt, D. M., Koulov, A. V., Coppinger, J., Gurkan, C., Kellner, W., Matteson, J., Plutner, H., Riordan, J. R., Kelly, J. W., et al. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis Cell  2006 127:803-815  DOI:10.1016/j.cell.2006.09.043  PMID:17110338