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Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

Academic Article
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Overview

authors

  • Boger, Dale
  • Labroli, M. A.
  • Marsilje, T. H.
  • Jin, Q.
  • Hedrick, M. P.
  • Baker, S. J.
  • Shim, J. H.
  • Benkovic, S. J.

publication date

  • 2000

journal

  • Bioorganic & Medicinal Chemistry  Journal

abstract

  • The synthesis and evaluation of a series of conformationally restricted analogues of 10-formyl-tetrahydrofolate as potential inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) or aminoimidazole carboxamide transformylase (AICAR Tfase) are reported.

subject areas

  • Cell Line
  • Cell Survival
  • Folic Acid Antagonists
  • Humans
  • Hydroxymethyl and Formyl Transferases
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Phosphoribosylglycinamide Formyltransferase
  • Tetrahydrofolate Dehydrogenase
  • Thymidylate Synthase
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Identity

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/s0968-0896(00)00051-1

PubMed ID

  • 10882019
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Additional Document Info

start page

  • 1075

end page

  • 1086

volume

  • 8

issue

  • 5

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