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Vasoactive intestinal polypeptide and muscarinic receptors: supersensitivity induced by long-term atropine treatment

Academic Article
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Overview

authors

  • Hedlund, B.
  • Abens, J.
  • Bartfai, Tamas

publication date

  • 1983

journal

  • Science  Journal

abstract

  • Long-term treatment of rats with atropine induced large increases in the numbers of muscarinic receptors and receptors for vasoactive intestinal polypeptide in the salivary glands. Since receptors for vasoactive intestinal polypeptide coexist with muscarinic receptors on the same neurons in this preparation, the results suggest that a drug that alters the sensitivity of one receptor may also affect the sensitivity of the receptor for a costored transmitter and in this way contribute to the therapeutic or side effects of the drugs.

subject areas

  • Animals
  • Atropine
  • Gastrointestinal Hormones
  • Male
  • Neurotransmitter Agents
  • Rats
  • Rats, Inbred Strains
  • Receptors, Cholinergic
  • Receptors, Muscarinic
  • Salivary Glands
  • Vasoactive Intestinal Peptide
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6132446

PubMed ID

  • 6132446
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Additional Document Info

start page

  • 519

end page

  • 521

volume

  • 220

issue

  • 4596

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