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Definition of 2 angiogenic pathways by distinct alpha(v) integrins

Academic Article
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Overview

authors

  • Friedlander, Martin
  • Brooks, P. C.
  • Shaffer, R. W.
  • Kincaid, C. M.
  • Varner, J. A.
  • Cheresh, D. A.

publication date

  • December 1995

journal

  • Science  Journal

abstract

  • Angiogenesis depends on cytokines and vascular cell adhesion events. Two cytokine-dependent pathways of angiogenesis were shown to exist and were defined by their dependency on distinct vascular cell integrins. In vivo angiogenesis in corneal or chorioallantoic membrane models induced by basic fibroblast growth factor or by tumor necrosis factor-alpha depended on alpha v beta 3, whereas angiogenesis initiated by vascular endothelial growth factor, transforming growth factor-alpha, or phorbol ester depended on alpha v beta 5. Antibody to each integrin selectively blocked one of these pathways, and a cyclic peptide antagonist of both integrins blocked angiogenesis stimulated by each cytokine tested. These pathways are further distinguished by their sensitivity to calphostin C, an inhibitor of protein kinase C that blocked angiogenesis potentiated by alpha v beta 5 but not by alpha v beta 3.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Chick Embryo
  • Cornea
  • Endothelial Growth Factors
  • Enzyme Inhibitors
  • Fibroblast Growth Factor 2
  • Integrins
  • Lymphokines
  • Naphthalenes
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Peptides, Cyclic
  • Protein Kinase C
  • Rabbits
  • Receptors, Vitronectin
  • Tetradecanoylphorbol Acetate
  • Transforming Growth Factor alpha
  • Tumor Necrosis Factor-alpha
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.270.5241.1500

PubMed ID

  • 7491498
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Additional Document Info

start page

  • 1500

end page

  • 1502

volume

  • 270

issue

  • 5241

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