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Antisense treatment of viral-infection

Academic Article
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Overview

authors

  • Whitton, J. Lindsay

publication date

  • 1994

journal

  • Advances in Virus Research  Journal

abstract

  • In this chapter I have attempted to outline the rationale that underlies the antisense approach to treatment of virus infection, to catalog the effector molecules that are currently available, and to estimate the relative worth of each. In so doing I have tried to describe the criteria that might be employed in their design and the factors that may determine their efficacy in tissue culture and, perhaps, in vivo. Finally, I have described the few examples presently available that indicate that antisense approaches may one day be therapeutically useful in treatment of disease of viral or nonviral origin.

subject areas

  • Animals
  • Base Sequence
  • Humans
  • Molecular Sequence Data
  • Oligonucleotides, Antisense
  • RNA, Antisense
  • RNA, Catalytic
  • Virus Diseases
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Identity

International Standard Serial Number (ISSN)

  • 0065-3527

Digital Object Identifier (DOI)

  • 10.1016/s0065-3527(08)60331-0

PubMed ID

  • 7817875
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Additional Document Info

start page

  • 267

end page

  • 303

volume

  • 44

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