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The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15

Academic Article
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Overview

authors

  • Ramsey, C.
  • Rubinstein, M. P.
  • Kim, Dae Hee
  • Cho, J. H.
  • Sprent, Jonathan
  • Surh, Charles

publication date

  • April 2008

journal

  • Journal of Immunology  Journal

abstract

  • Homeostatic proliferation for naive T cells is observed readily only under lymphopenic conditions in response to elevated levels of IL-7 and contact with self-MHC/peptide ligands. Homeostatic proliferation occurs at a slow pace and gradually induces the dividing cells to acquire characteristics of memory cells. We describe a novel type of homeostatic proliferation whereby naive T cells proliferate at a significantly faster rate, resembling the proliferation speed induced by foreign Ags, and the expanding cells rapidly differentiate into central memory cells. Remarkably, such rapid homeostatic proliferation is driven by a combination of IL-2 and IL-15, with IL-15 playing a bigger role, and applies for a wide repertoire of CD8(+) naive T cells, including many TCR-transgenic lines, even those that fail to undergo IL-7-driven homeostatic proliferation. Thus, naive T cells can be induced to undergo homeostatic proliferation of variable speed with a few members of the common gamma-chain (CD132) family of cytokines, the speed of proliferation depending on the levels of the particular cytokine involved.

subject areas

  • Animals
  • CD8-Positive T-Lymphocytes
  • Cell Proliferation
  • Homeostasis
  • Interleukin Receptor Common gamma Subunit
  • Interleukin-15
  • Interleukin-2
  • Interleukin-7
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Mice, Transgenic
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 18390713
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Additional Document Info

start page

  • 5320

end page

  • 5326

volume

  • 180

issue

  • 8

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