Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Serial backcross mapping of multiple loci associated with resistance to leishmania major in mice

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Beebe, A. M.
  • Mauze, S.
  • Schork, Nicholas
  • Coffman, R. L.

publication date

  • May 1997

journal

  • Immunity  Journal

abstract

  • Resistance or susceptibility of inbred mouse strains to the parasite Leishmania major correlates with CD4+ T cell responses of the Th1 or Th2 subsets, respectively. To evaluate the genetic basis for this difference, resistant B10.D2 mice were backcrossed onto susceptible BALB/c mice for five generations with selection for resistance. Candidate resistance loci were identified by high frequency of heterozygosity in resistant N5 backcross mice. Loci on chromosomes 6, 7, 10, 11, 15, and 16 were associated with resistance, demonstrating the multigenic nature of this phenotype. The presence of all six loci was not necessary to confer resistance and no single locus was required. Rather, a variety of combinations of these loci may be capable of interacting to confer resistance.

subject areas

  • Animals
  • Chromosome Mapping
  • Crosses, Genetic
  • Disease Susceptibility
  • Female
  • Genotype
  • Immunity, Innate
  • Leishmania major
  • Leishmaniasis, Cutaneous
  • Linkage Disequilibrium
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Pedigree
  • Phenotype
  • Probability
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)80343-x

PubMed ID

  • 9175833
scroll to property group menus

Additional Document Info

start page

  • 551

end page

  • 557

volume

  • 6

issue

  • 5

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support