recent publications

• academic article

  • Schmidt, R. J., Ficorilli, J. V., Zhang, Y. Y., Bramlett, K. S., Beyer, T. P., Borchert, K., Dowless, M. S., Houck, K. A., Burris, T. P., Eacho, P. I., Liang, G. S., Guo, L. W., et al. A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity Journal of Lipid Research  2006 47:1037-1044  DOI:10.1194/jlr.M500526-JLR200  PMID:16415294
  • Savkur, R. S., Thomas, J. S., Bramlett, K. S., Gao, Y. L., Michael, L. F., Burris, T. P. Ligand-dependent coactivation of the human bile acid receptor fxr by the peroxisome proliferator-activated receptor gamma coactivator-1 alpha Journal of Pharmacology and Experimental Therapeutics  2005 312:170-178  DOI:10.1124/jpet.104.072124  PMID:15329387
  • Stayrook, K. R., Bramlett, K. S., Savkur, R. S., Ficorilli, J., Cook, T., Christe, M. E., Michael, L. F., Burris, T. P. Regulation of carbohydrate metabolism by the farnesoid x receptor Endocrinology  2005 146:984-991  DOI:10.1210/en.2004-0965  PMID:15564327
  • Savkur, R. S., Bramlett, K. S., Michael, L. F., Burris, T. P. Regulation of pyruvate dehydrogenase kinase expression by the farnesoid x receptor Biochemical and Biophysical Research Communications  2005 329:391-396  DOI:10.1016/j.bbrc.2005.01.141  PMID:15721319
  • Michael, L. F., Schkeryantz, J. M., Burris, T. P. The pharmacology of lxr Mini-Reviews in Medicinal Chemistry  2005 5:729-740  DOI:10.2174/1389557054553767  PMID:16101409
  • Houck, K. A., Borchert, K. M., Hepler, C. D., Thomas, J. S., Bramlett, K. S., Michael, L. F., Burris, T. P. T0901317 is a dual lxr/fxr agonist Molecular Genetics and Metabolism  2004 83:184-187  DOI:10.1016/j.ymgme.2004.07.007  PMID:15464433
  • Thomas, J., Bramlett, K. S., Montrose, C., Foxworthy, P., Eacho, P. I., McCann, D., Cao, G. Q., Kiefer, A., McCowan, J., Yu, K. L., Grese, T., Chin, W. W., et al. A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor Journal of Biological Chemistry  2003 278:2403-2410  DOI:10.1074/jbc.M209629200  PMID:12441342
  • Bramlett, K. S., Houck, K. A., Borchert, K. M., Dowless, M. S., Kulanthaivel, P., Zhang, Y. Y., Beyer, T. P., Schmidt, R., Thomas, J. S., Michael, L. F., Barr, R., Montrose, C., et al. A natural product ligand of the oxysterol receptor, liver x receptor Journal of Pharmacology and Experimental Therapeutics  2003 307:291-296  DOI:10.1124/jpet.103.052852  PMID:12893846
  • Wang, M. M., Thomas, J., Burris, T. P., Schkeryantz, J., Michael, L. F. Molecular determinants of lxr alpha agonism Journal of Molecular Graphics & Modelling  2003 22:173-181  DOI:10.1016/s1093-3263(03)00159-1  PMID:12932788
  • Michael, L. F., Asahara, H., Shulman, A. I., Kraus, W. L., Montminy, M. The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism Molecular and Cellular Biology  2000 20:1596-1603  DOI:10.1128/mcb.20.5.1596-1603.2000  PMID:10669737