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Semaphorin 3a is a chemoattractant for cortical apical dendrites

Academic Article
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Overview

authors

  • Polleux, Franck
  • Morrow, T.
  • Ghosh, A.

publication date

  • April 2000

journal

  • Nature  Journal

abstract

  • The apical dendrites of pyramidal neurons integrate inputs from various cortical layers and are central to information processing. Here we show that the growth of apical dendrites towards the pial surface is regulated by a diffusible chemoattractant present at high levels near the marginal zone. A major component of this signal is semaphorin 3A (Sema3A), which was previously characterized as a chemorepellant for cortical axons. Soluble guanylate cyclase is asymmetrically localized to the developing apical dendrite, and is required for the chemoattractive effect of Sema3A. Thus the asymmetric localization of soluble guanylate cyclase confers distinct Sema3A responses to axons and dendrites. These observations reveal a mechanism by which a single chemotropic signal can pattern both axons and dendrites during development.

subject areas

  • Animals
  • Axons
  • Cells, Cultured
  • Cerebral Cortex
  • Chemotactic Factors
  • Coculture Techniques
  • Cyclic GMP-Dependent Protein Kinases
  • Dendrites
  • Glycoproteins
  • Green Fluorescent Proteins
  • Guanylate Cyclase
  • Luminescent Proteins
  • Mice
  • Mice, Transgenic
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Neuropilin-1
  • Protein Kinases
  • Pyramidal Cells
  • Rats
  • Receptors, Cell Surface
  • Semaphorin-3A
  • Signal Transduction
  • Solubility
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

PubMed ID

  • 10766232
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Additional Document Info

start page

  • 567

end page

  • 573

volume

  • 404

issue

  • 6778

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