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B cell receptor expression level determines the fate of developing b lymphocytes: Receptor editing versus selection

Academic Article
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Overview

authors

  • Kouskoff, V.
  • Lacaud, G.
  • Pape, K.
  • Retter, M.
  • Nemazee, David

publication date

  • June 2000

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • During B lymphocyte development, antibody genes are assembled by DNA recombination. Successful cell surface expression of IgM promotes developmental progression. However, when antigen receptors bind autoantigen, development is blocked and ongoing antibody gene recombination occurs, which often alters antibody specificity in a process called receptor editing. We demonstrate here a significant role of developmental block and receptor editing in B cell receptor quality control. During development a functional, non-self-reactive receptor undergoes receptor editing if its expression is below a certain threshold. Doubling the receptor gene dose promotes development in the absence of autoantigen, but allows editing when autoantigen is present. Thus, both underexpressed and harmful B cell receptors can undergo correction by receptor editing.

subject areas

  • Animals
  • B-Lymphocytes
  • Cell Differentiation
  • Mice
  • Receptors, Antigen, B-Cell
  • Recombination, Genetic
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Identity

PubMed Central ID

  • PMC16563

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.130182597

PubMed ID

  • 10829082
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Additional Document Info

start page

  • 7435

end page

  • 7439

volume

  • 97

issue

  • 13

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