recent publications

• academic article

  • Mehta, R. H., Stebbins, A. S., Lopes, R. D., Califf, R. M., Pieper, K. S., Armstrong, P. W., Van de Werf, F., Hochman, J. S., White, H. D., Topol, E. J., Alexander, J. H., Granger, C. B. Comparison of incidence of bleeding and mortality of men versus women with st-elevation myocardial infarction treated with fibrinolysis American Journal of Cardiology  2012 109:320-326  DOI:10.1016/j.amjcard.2011.09.012  PMID:22078221
  • Mehta, R. H., O'Shea, J. C., Stebbins, A. L., Granger, C. B., Armstrong, P. W., White, H. D., Topol, E. J., Califf, R. M., Ohman, E. M. Association of mortality with years of education in patients with st-segment elevation myocardial infarction treated with fibrinolysis Journal of the American College of Cardiology  2011 57:138-146  DOI:10.1016/j.jacc.2010.09.021  PMID:21211684
  • Herrmann, H. C., Lu, J. D., Brodie, B. R., Armstrong, P. W., Montalescot, G., Betriu, A., Neuman, F. J., Effron, M. B., Barnathan, E. S., Topol, E. J., Ellis, S. G., Investigators, Finesse Benefit of facilitated percutaneous coronary intervention in high-risk st-segment elevation myocardial infarction patients presenting to nonpercutaneous coronary intervention hospitals JACC-Cardiovascular Interventions  2009 2:917-924  DOI:10.1016/j.jcin.2009.06.018  PMID:19850249
  • Berger, J. S., Elliott, L., Gallup, D., Roe, M., Granger, C. B., Armstrong, P. W., Simes, R. J., White, H. D., Van de Werf, F., Topol, E. J., Hochman, J. S., Newby, L. K., et al. Sex differences in mortality following acute coronary syndromes JAMA-Journal of the American Medical Association  2009 302:874-882  DOI:10.1001/jama.2009.1227  PMID:19706861  PMCID:PMC2778841
  • Mehta, R. H., Califf, R. M., Garg, J., White, H. D., Van de Werf, F., Armstrong, P. W., Pieper, K. S., Topol, E. J., Granger, C. B. The impact of anthropomorphic indices on clinical outcomes in patients with acute st-elevation myocardial infarction European Heart Journal  2007 28:415-424  DOI:10.1093/eurheartj/ehl329  PMID:17040928
  • Goodman, S. G., Fu, Y. L., Langer, A., Barr, A., Tan, M., Wagner, G. S., Barbagelata, A., Sgarbossa, E. B., Birnbaum, Y., Granger, C. B., Califf, R. M., Van de Werf, F., et al. The prognostic value of the admission and predischarge electrocardiogram in acute coronary syndromes: The gusto-iib ecg core laboratory experience American Heart Journal  2006 152:277-284  DOI:10.1016/j.ahj.2005.12.022  PMID:16875908
  • Galla, J. M., Mahaffey, K. W., Sapp, S. K., Alexander, J. H., Roe, M. T., Ohman, E. M., Granger, C. B., Armstrong, P. W., Harrington, R. A., White, H. D., Simoons, M. L., Newby, L. K., et al. Elevated creatine kinase-mb with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: Results from 4 large clinical trials American Heart Journal  2006 151:16-24  DOI:10.1016/j.ahj.2005.01.045  PMID:16368286
  • Brener, S. J., Lincoff, A. M., Bates, E. R., Jia, G., Armstrong, P. W., Guetta, V., Hochman, J. S., Savonitto, S., Wilcox, R. G., White, H. D., Topol, E. J., Investigators, Gusto V. The relationship between baseline risk and mortality in st-elevation acute myocardial infarction treated with pharmacological reperfusion: Insights from the global utilization of strategies to open occluded arteries (gusto) v trial American Heart Journal  2005 150:89-93  DOI:10.1016/j.ahj.2005.01.030  PMID:16084153
  • Labinaz, M., Mathias, J., Pieper, K., Granger, C. B., Lincoff, A. M., Moliterno, D. J., Van de Werf, F., Simes, J., White, H. D., Simoons, M. L., Califf, R. M., Topol, E. J., et al. Outcomes of patients with acute coronary syndromes and prior percutaneous coronary intervention: A pooled analysis of three randomized clinical trials European Heart Journal  2005 26:128-136  DOI:10.1093/eurheartj/ehi061  PMID:15618068
  • Rao, S. V., Jollis, J. G., Harrington, R. A., Granger, C. B., Newby, L. K., Armstrong, P. W., Moliterno, D. J., Lindblad, L., Pieper, K., Topol, E. J., Stamler, J. S., Califf, R. M. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes JAMA-Journal of the American Medical Association  2004 292:1555-1562  DOI:10.1001/jama.292.13.1555  PMID:15467057
  • Kaul, P., Armstrong, P. W., Chang, W. C., Naylor, C. D., Granger, C. B., Lee, K. L., Peterson, E. D., Califf, R. M., Topol, E. J., Mark, D. B. Long-term mortality of patients with acute myocardial infarction in the united states and canada - comparison of patients enrolled in global utilization of streptokinase and t-pa for occluded coronary arteries (gusto)-i Circulation  2004 110:1754-1760  DOI:10.1161/01.cir.0000142671.06167.91  PMID:15381645
  • Gurm, H. S., Lincoff, A. M., Lee, D., Tang, W. H. W., Jia, G., Booth, J. E., Califf, R. M., Ohman, E. M., Van de Werf, F., Armstrong, P. W., Guetta, V., Wilcox, R., et al. Outcome of acute st-segment elevation myocardial infarction in diabetics treated with fibrinolytic or combination reduced fibrinolytic therapy and platelet glycoprotein iib/iiia inhibition - lessons from the gusto v trial Journal of the American College of Cardiology  2004 43:542-548  DOI:10.1016/j.jacc.2003.09.038  PMID:14975461
  • Kaul, P., Newby, L. K., Fu, Y. L., Mark, D. B., Califf, R. M., Topol, E. J., Aylward, P., Granger, C. B., Van de Werf, F., Armstrong, P. W., Grp, Vigour International differences in evolution of early discharge after acute myocardial infarction Lancet  2004 363:511-517  DOI:10.1016/s0140-6736(04)15536-0  PMID:14975612
  • Roe, M. T., Mahaffey, K. W., Kilaru, R., Alexander, J. H., Akkerhuis, K. M., Simoons, M. L., Harrington, R. A., Tardiff, B. E., Granger, C. B., Ohman, E. M., Moliterno, D. J., Lincoff, A. M., et al. Creatine kinase-mb elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes European Heart Journal  2004 25:313-321  DOI:10.1016/j.ehj.2003.12.009  PMID:14984920
  • Kramer, J. M., Newby, L. K., Chang, W. C., Simes, R. J., Van de Werf, F., Granger, C. B., Lee, K. L., White, H. D., Piegas, L. S., Topol, E. J., Califf, R. M., Armstrong, P. W., et al. International variation in the use of evidence-based medicines for acute coronary syndromes European Heart Journal  2003 24:2133-2141  DOI:10.1016/j.ehj.2003.09.018  PMID:14643274
  • Savonitto, S., Armstrong, P. W., Lincoff, A. M., Jia, G., Sila, C. A., Booth, J., Terrosu, P., Cavallini, C., White, H. D., Ardissino, D., Califf, R. M., Topol, E. J., et al. Risk of intracranial haemorrhage with combined fibrinolytic and glycoprotein iib/iiia inhibitor therapy in acute myocardial infarction - dichotomous response as a function of age in the gusto v trial European Heart Journal  2003 24:1807-1814  DOI:10.1016/j.ehj.2003.07.004  PMID:14563339
  • Khadour, F. H., Fu, Y. L., Chang, W. C., Ma, X., Mark, D., Granger, C. B., Topol, E. J., Califf, R. M., Armstrong, P. W., investigators, Gusto IIb Impact of on-site cardiac interventional facilities on management and outcome of patients with acute coronary syndromes Canadian Journal of Cardiology  2003 19:257-263  PMID:12677281
  • Al-Khatib, S. M., Stebbins, A. L., Califf, R. M., Lee, K. L., Granger, C. B., White, H. D., Armstrong, P. W., Topol, E. J., Ohman, E. M. Sustained ventricular arrhythmias and mortality among patients with acute myocardial infarction: Results from the gusto-iii trial American Heart Journal  2003 145:515-521  DOI:10.1067/mhj.2003.170  PMID:12660676
  • Kaul, P., Newby, L. K., Fu, Y. L., Hasselblad, V., Mahaffey, K. W., Christenson, R. H., Harrington, R. A., Ohman, E. M., Topol, E. J., Califf, R. M., Van de Werf, F., Armstrong, P. W., et al. Troponin t and quantitative st-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients Journal of the American College of Cardiology  2003 41:371-380  DOI:10.1016/s0735-1097(02)02824-3  PMID:12575962
  • Grines, C., Patel, A., Zijlstra, F., Weaver, W. D., Granger, C., Simes, R. J., Ellis, S., Betriu, A., Garcia, E., Grinfeld, L., Gibbons, R., Ribeiro, E., et al. Primary coronary angioplasty compared with intravenous thrombolytic therapy for acute myocardial infarction: Six-month follow up and analysis of individual patient data from randomized trials American Heart Journal  2003 145:47-57  DOI:10.1067/mhj.2003.40  PMID:12514654
  • Newby, L. K., Hasselblad, V., Armstrong, P. W., Van de Werf, F. V., Mark, D. B., White, H. D., Topol, E. J., Califf, R. M. Time-based risk assessment after myocardial infarction. Implications for timing of discharge and applications to medical decision-making European Heart Journal  2003 24:182-189  DOI:10.1016/s0195-668x(03)00301-9  PMID:12573275
  • Lincoff, A. M., Califf, R. M., Van de Werf, F., Willerson, J. T., White, H. D., Armstrong, P. W., Guetta, V., Gibler, W. B., Hochman, J. S., Bode, C., Vahanian, A., Steg, P. G., et al. Mortality at 1 year with combination platelet glycoprotein iib/iiia inhibition and reduced-dose fibrinolytic therapy vs conventional fibrinolytic therapy for acute myocardial infarction - gusto v randomized trial JAMA-Journal of the American Medical Association  2002 288:2130-2135  DOI:10.1001/jama.288.17.2130  PMID:12413372
  • Al-Khatib, S. M., Granger, C. B., Huang, Y., Lee, K. L., Califf, R. M., Simoons, M. L., Armstrong, P. W., Van de Werf, F., White, H. D., Simes, R. J., Moliterno, D. J., Topol, E. J., et al. Sustained ventricular arrhythmias among patients with acute coronary syndromes with no st-segment elevation - incidence, predictors, and outcomes Circulation  2002 106:309-312  DOI:10.1161/01.cir.0000022692.49934.e3  PMID:12119245
  • Anderson, R. D., White, H. D., Ohman, E. M., Wagner, G. S., Krucoff, M. W., Armstrong, P. W., Weaver, W. D., Gibler, W. B., Stebbins, A. L., Califf, R. M., Topol, E. J. Predicting outcome after thrombolysis in acute myocardial infarction according to st-segment resolution at 90 minutes: A substudy of the gusto-iii trial American Heart Journal  2002 144:81-88  DOI:10.1067/mhj.2002.123319  PMID:12094192
  • Cantor, W. J., Newby, L. K., Christenson, R. H., Tuttle, R. H., Hasselblad, V., Armstrong, P. W., Moliterno, D. J., Califf, R. M., Topol, E. J., Ohman, E. M., Investigators, Symphony, Investigators, 2nd Symphony Prognostic significance of elevated troponin i after percutaneous coronary intervention Journal of the American College of Cardiology  2002 39:1738-1744  DOI:10.1016/s0735-1097(02)01877-6  PMID:12039485
  • Mahaffey, K. W., Roe, M. T., Dyke, C. K., Newby, L. K., Kleiman, N. S., Connolly, P., Berdan, L. G., Sparapani, R., Lee, K. L., Armstrong, P. W., Topol, E. J., Califf, R. M., et al. Misreporting of myocardial infarction end points: Results of adjudication by a central clinical events committee in the paragon-b trial American Heart Journal  2002 143:242-248  DOI:10.1067/mhj.2002.120145  PMID:11835026
  • Gibler, W. B., Armstrong, P. W., Ohman, E. M., Weaver, W. D., Stebbins, A. L., Gore, J. M., Newby, L. K., Califf, R. M., Topol, E. J., Investigators, Gusto Persistence of delays in presentation and treatment for patients with acute myocardial infarction: The gusto-i and gusto-iii experience Annals of Emergency Medicine  2002 39:123-130  DOI:10.1067/mem.2002.121402  PMID:11823765
  • Labinaz, M., Kilaru, R., Pieper, K., Marso, S. P., Kitt, M. M., Simoons, M. L., Califf, R. M., Topol, E. J., Armstrong, P. W., Harrington, R. A., Investigators, Pursuit Outcomes of patients with acute coronary syndromes and prior coronary artery bypass grafting - results from the platelet glycoprotein iib/iiia in unstable angina: Receptor suppression using integrilin therapy (pursuit) trial Circulation  2002 105:322-327  DOI:10.1161/hc0302.102578  PMID:11804987
  • Savonitto, S., Granger, C. B., Ardissino, D., Gardner, L., Cavallini, C., Galvani, M., Ottani, F., White, H. D., Armstrong, P. W., Ohman, E. M., Pieper, K. S., Califf, R. M., et al. The prognostic value of creatine kinase elevations extends across the whole spectrum of acute coronary syndromes Journal of the American College of Cardiology  2002 39:22-29  DOI:10.1016/s0735-1097(01)01706-5  PMID:11755282
  • O'Shea, J. C., Wilcox, R. G., Skene, A. M., Stebbins, A. L., Granger, C. B., Armstrong, P. W., Bode, C., Ardissino, D., Emanuelsson, H., Aylward, P. H. E., White, H. D., Sadowski, Z., et al. Comparison of outcomes of patients with myocardial infarction when living alone versus those not living alone American Journal of Cardiology  2002 90:1374-1377  DOI:10.1016/s0002-9149(02)02876-x  PMID:12480048
  • Boersma, E., Harrington, R. A., Moliterno, D. J., White, H., Theroux, P., Van de Werf, F., de Torbal, A., Armstrong, P. W., Wallentin, L. C., Wilcox, R. G., Simes, J., Califf, R. M., et al. Platelet glycoprotein iib/iiia inhibitors in acute coronary syndromes: A meta-analysis of all major randomised clinical trials Lancet  2002 359:189-198  DOI:10.1016/s0140-6736(02)07442-1  PMID:11812552
  • Roe, M. T., Granger, C. B., Puma, J. A., Hellkamp, A. S., Hochman, J. S., Ohman, E. M., White, H. D., Van de Werf, F., Armstrong, P. W., Ellis, S. G., Califf, R. M., Topol, E. J. Comparison of benefits and complications of hirudin versus heparin for patients with acute coronary syndromes undergoing early percutaneous coronary intervention American Journal of Cardiology  2001 88:1403-6, A6  DOI:10.1016/s0002-9149(01)02119-1  PMID:11741559
  • White, H. D., Simes, R. J., Aylward, P. E. G., Armstrong, P. W., Califf, R. M., French, J. K., Granger, C. B., Marschner, I. C., Topol, E. J., Van de Werf, F. J., Wilcox, R. G., Hirulog Early Reperfusion, Occlusi Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: The hero-2 randomised trial Lancet  2001 358:1855-1863  PMID:11741625
  • Hudson, M. P., Granger, C. B., Topol, E. J., Pieper, K. S., Armstrong, P. W., Barbash, G. I., Guerci, A. D., Vahanian, A., Califf, R. M., Ohman, E. M. Early reinfarction after fibrinolysis - experience from the global utilization of streptokinase and tissue plasminogen activator (alteplase) for occluded coronary arteries (gusto i) and global use of strategies to open occluded coronary arteries (gusto iii) trials Circulation  2001 104:1229-1235  DOI:10.1161/hc3601.095717  PMID:11551872
  • Kaul, P., Fu, Y. L., Chang, W. C., Harrington, R. A., Wagner, G. S., Goodman, S. G., Granger, C. B., Moliterno, D. J., Van de Werf, F., Califf, R. N., Topol, E. J., Armstrong, P. W., et al. Prognostic value of st segment depression in acute coronary syndromes: Insights from paragon-a applied to gusto-iib Journal of the American College of Cardiology  2001 38:64-71  DOI:10.1016/s0735-1097(01)01307-9  PMID:11451297
  • Newby, L. K., Ohman, E. M., Christenson, R. H., Moliterno, D. J., Harrington, R. A., White, H. D., Armstrong, P. W., Van de Werf, F., Pfisterer, M., Hasselblad, V., Califf, R. M., Topol, E. J., et al. Benefit of glycoprotein iib/iiia inhibition in patients with acute coronary syndromes and troponin t-positive status - the paragon-b troponin t substudy Circulation  2001 103:2891-2896  DOI:10.1161/‚Äã01.CIR.103.24.2891  PMID:11413076
  • Topol, E. J., Califf, R. M., Van de Werf, F., Willerson, J. T., Booth, J., White, H., Clayman, M., Deckelbaum, L., Lincoff, A. M., Ohman, E. M., Bates, E., Gibler, W. B., et al. Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein iib/iiia inhibition: The gusto randomised trial Lancet  2001 357:1905-1914  PMID:11425410
  • Aronow, H. D., Topol, E. J., Roe, M. T., Houghtaling, P. L., Wolski, K. E., Lincoff, A. M., Harrington, R. A., Califf, R. M., Ohman, E. M., Kleiman, N. S., Keltai, M., Wilcox, R. G., et al. Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: An observational study Lancet  2001 357:1063-1068  DOI:10.1016/s0140-6736(00)04257-4  PMID:11297956
  • Bahit, M. C., Topol, E. J., Califf, R. M., Armstrong, P. W., Criger, D. A., Hasselblad, V., Betriu, A., Hirsh, J., Ardissino, D., Granger, C. B. Reactivation of ischemic events in acute coronary syndromes: Results from gusto-iib Journal of the American College of Cardiology  2001 37:1001-1007  DOI:10.1016/s0735-1097(01)01143-3  PMID:11263599
  • Topol, E. J., Ohman, E. M., Armstrong, P. W., Wilcox, R., Skene, A. M., Aylward, P., Simes, J., Dalby, A., Betriu, A., Bode, C., White, H. D., Hochman, J. S., et al. Survival outcomes 1 year after reperfusion therapy with either alteplase or reteplase for acute myocardial infarction - results from the global utilization of streptokinase and t-pa for occluded coronary arteries (gusto) iii trial Circulation  2000 102:1761-1765  PMID:11023929
  • Chang, W. C., Fu, Y. L., Ohman, E. M., Gupta, M., Morris, A., Roth, S. N., Granger, C. B., Califf, R. M., Topol, E. J., Mark, D. B., Armstrong, P. W., Investigators, N. Am GUSTO-I GUSTO-III Temporal evolution in the management of acute st elevation myocardial infarction: The seven-year gusto experience from canada and the united states Canadian Journal of Cardiology  2000 16:1231-1239  PMID:11064297
  • Fu, Y. L., Chang, W. C., Mark, D., Califf, R. M., Mackenzie, B., Granger, C. B., Topol, E. J., Hlatky, M., Armstrong, P. W., Investigators, Gusto IIb Canadian-american differences in the management of acute coronary syndromes in the gusto iib trial - one-year follow-up of patients without st-segment elevation Circulation  2000 102:1375-1381  PMID:10993855
  • Harrington, R. A., Armstrong, P. W., Graffagnino, C., Van de Werf, F., Kereiakes, D. J., Sigmon, K. N., Card, T., Joseph, D. M., Samuels, R., Granett, J., Chan, R., Califf, R. M., et al. Dose-finding, safety, and tolerability study of an oral platelet glycoprotein IIb/IIIa inhibitor, lotrafiban, in patients with coronary or cerebral atherosclerotic disease Circulation  2000 102:728-735  PMID:10942739
  • Boersma, E., Pieper, K. S., Steyerberg, E. W., Wilcox, R. G., Chang, W. C., Lee, K. L., Akkerhuis, K. M., Harrington, R. A., Deckers, J. W., Armstrong, P. W., Lincoff, A. M., Califf, R. M., et al. Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation results from an international trial of 9461 patients Circulation  2000 101:2557-2567  PMID:10840005
  • Califf, R. M., Pieper, K. S., Lee, K. L., Van de Werf, F., Simes, R. J., Armstrong, P. W., Topol, E. J., Investigators, Gusto- I. Prediction of 1-year survival after thrombolysis for acute myocardial infarction in the global utilization of streptokinase and tpa for occluded coronary arteries trial Circulation  2000 101:2231-2238  PMID:10811588
  • Newby, L. K., Eisenstein, E. L., Califf, R. M., Thompson, T. D., Nelson, C. L., Peterson, E. D., Armstrong, P. W., Van de Werf, F., White, H. D., Topol, E. J., Mark, D. B. Cost effectiveness of early discharge after uncomplicated acute myocardial infarction New England Journal of Medicine  2000 342:749-755  DOI:10.1056/nejm200003163421101  PMID:10717009
  • Topol, C. E., Califf, R. M., Simes, R. J., Van de Werf, F., Diaz, R., Paolasso, E., Aylward, P. E., Keech, A., Klein, W., Piegas, L., Tomov, I., Armstrong, P. W., et al. Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial Lancet  2000 355:337-345  PMID:10665552
  • Hasdai, D., Califf, R. M., Thompson, T. D., Hochman, J. S., Ohman, E. M., Pfisterer, M., Bates, E. R., Vahanian, A., Armstrong, P. W., Criger, D. A., Topol, E. J., Holmes, D. R. Predictors of cardiogenic shock after thrombolytic therapy for acute myocardial infarction Journal of the American College of Cardiology  2000 35:136-143  DOI:10.1016/s0735-1097(99)00508-2  PMID:10636271
  • Ohman, E. M., Armstrong, P. W., White, H. D., Granger, C. B., Wilcox, R. G., Weaver, W. D., Gibler, W. B., Stebbins, A. L., Cianciolo, C., Califf, R. M., Topol, E. J., GUSTO III Investigators Risk stratification with a point-of-care cardiac troponin t test in acute myocardial infarction American Journal of Cardiology  1999 84:1281-1286  DOI:10.1016/s0002-9149(99)00558-5  PMID:10614791
  • Van de Werf, F., Adgey, J., Ardissino, D., Armstrong, P. W., Aylward, P., Barbash, G., Betriu, A., Binbrek, A. S., Califf, R., Diaz, R., Fanebust, R., Fox, K., et al. Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: The assent-2 double-blind randomised trial Lancet  1999 354:716-722  DOI:10.1016/s0140-6736(99)07403-6  PMID:10475182
  • Alexander, J. H., Harrington, R. A., Tuttle, R. H., Berdan, L. G., Lincoff, A. M., Deckers, J. W., Simoons, M. L., Guerci, A., Hochman, J. S., Wilcox, R. G., Kitt, M. M., Eisenberg, P. R., et al. Prior aspirin use predicts worse outcomes in patients with non-st-elevation acute coronary syndromes American Journal of Cardiology  1999 83:1147-1151  DOI:10.1016/s0002-9149(99)00049-1  PMID:10215274
  • Hasdai, D., Holmes, D. R., Topol, E. J., Berger, P. B., Criger, D. A., Hochman, J. S., Bates, E. R., Vahanian, A., Armstrong, P. W., Wilcox, R., Ohman, E. M., Califf, R. M. Frequency and clinical outcome of cardiogenic shock during acute myocardial infarction among patients receiving reteplase or alteplase - results from gusto-iii European Heart Journal  1999 20:128-135  DOI:10.1053/euhj.1999.1282  PMID:10099909
  • Alexander, K. P., Peterson, E. D., Granger, C. B., Casas, A. C., Van de Werf, F., Armstrong, P. W., Guerci, A., Topol, E. J., Califf, R. M., Investigators, G. USTO-IIb Potential impact of evidence-based medicine in acute coronary syndromes: Insights from gusto-iib Journal of the American College of Cardiology  1998 32:2023-2030  DOI:10.1016/s0735-1097(98)00466-5  PMID:9857888
  • Armstrong, P. W., Fu, Y. L., Chang, W. C., Topol, E. J., Granger, C. B., Betriu, A., Van de Werf, F., Lee, K. L., Califf, R. M., Investigators, G. USTO-IIb Acute coronary syndromes in the gusto-iib trial - prognostic insights and impact of recurrent ischemia Circulation  1998 98:1860-1868  PMID:9799205
  • Newby, L. K., Christenson, R. H., Ohman, E. M., Armstrong, P. W., Thompson, T. D., Lee, K. L., Hamm, C. W., Katus, H. A., Cianciolo, C., Granger, C. B., Topol, E. J., Califf, R. M., et al. Value of serial troponin t measures for early and late risk stratification in patients with acute coronary syndromes Circulation  1998 98:1853-1859  PMID:9799204
  • Pfisterer, M., Cox, J. L., Granger, C. B., Brener, S. J., Naylor, C. D., Califf, R. M., van de Werf, F., Stebbins, A. L., Lee, K. L., Topol, E. J., Armstrong, P. W., Investigators, Gusto- I. Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: The gusto-i experience Journal of the American College of Cardiology  1998 32:634-640  DOI:10.1016/s0735-1097(98)00279-4  PMID:9741504
  • Metz, B. K., White, H. D., Granger, C. B., Simes, R. J., Armstrong, P. W., Hirsh, J., Fuster, V., MacAulay, C. M., Califf, R. M., Topol, E. J., Global Use Strategies Open Occluded Coronary, A. Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: Results from the gusto-iib trial Journal of the American College of Cardiology  1998 31:1493-1498  DOI:10.1016/s0735-1097(98)00138-7  PMID:9626825
  • Hochrein, J., Sun, F. C., Pieper, K. S., Lee, K. L., Gates, K. B., Armstrong, P. W., Weaver, W. D., Goodman, S. G., Topol, E. J., Califf, R. M., Granger, C. B., Wagner, G. S. Higher t-wave amplitude associated with better prognosis in patients receiving thrombolytic therapy for acute myocardial infarction (a gusto-i substudy) American Journal of Cardiology  1998 81:1078-1084  DOI:10.1016/s0002-9149(98)00112-x  PMID:9605045
  • Christenson, R. H., Duh, S. H., Newby, L. K., Ohman, E. M., Califf, R. M., Granger, C. B., Peck, S., Pieper, K. S., Armstrong, P. W., Katus, H. A., Topol, E. J., Investigators, G. USTO-IIa Cardiac troponin t and cardiac troponin i: Relative values in short-term risk stratification of patients with acute coronary syndromes Clinical Chemistry  1998 44:494-501  PMID:9510853
  • Goodman, S. G., Langer, A., Ross, A. M., Wildermann, N. M., Barbagelata, A., Sgarbossa, E. B., Wagner, G. S., Granger, C. B., Califf, R. M., Topol, E. J., Simoons, M. L., Armstrong, P. W., et al. Non-q-wave versus q-wave myocardial infarction after thrombolytic therapy - angiographic and prognostic insights from the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries-i angiographic substudy Circulation  1998 97:444-450  PMID:9490238
  • Berkowitz, S. D., Granger, C. B., Peiper, K. S., Lee, K. L., Gore, J. M., Simoons, M., Armstrong, P. W., Topol, E. J., Califf, R. M. Incidence and predictors of bleeding after contemporary thrombolytic therapy for myocardial infarction Circulation  1997 95:2508-2516  PMID:9184581
  • Topol, E. J., Califf, R. M., VandeWerf, F., Simoons, M., Hampton, J., Lee, K. L., White, H., Simes, J., Armstrong, P. W. Perspectives on large-scale cardiovascular clinical trials for the new millennium Circulation  1997 95:1072-1082  PMID:9054772
  • Betriu, A., Phillips, H., Ellis, S., Topol, E., Califf, R., VanderWerf, F., Ardissino, D., Armstrong, P. W., Aylward, P., Bates, E., Beatt, K., Cheseboro, J., et al. A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction New England Journal of Medicine  1997 336:1621-1628  PMID:9173270
  • Krucoff, M. W., Green, C. L., Langer, A., Klootwijk, P., Trollinger, K. M., Pope, J. E., Armstrong, P. W., Simoons, M. L., Topol, E. J., Califf, R. M. Continuous 12-lead st-segment recovery predicts outcome in acute myocardial infarction better than "snapshot" angiograms of timi flow Journal of Electrocardiology  1997 30:167-167
  • Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., Ohanesian, M. A., Wagner, G. S., Kleiman, N. S., Harrell, F. E., Califf, R. M., Topol, E. J. Cardiac troponin t levels for risk stratification in acute myocardial ischemia New England Journal of Medicine  1996 335:1333-1341  DOI:10.1056/nejm199610313351801  PMID:8857016
  • Califf, R. M., White, H. D., VandeWerf, E. V., Sadowski, Z., Armstrong, P. W., Vahanian, A., Simoons, M. L., Simes, R. J., Lee, K. L., Topol, E. J. One-year results from the global utilization of streptokinase and tpa for occluded coronary arteries (gusto-i) trial Circulation  1996 94:1233-1238  PMID:8822974
  • Newby, L. K., Rutsch, W. R., Califf, R. M., Simoons, M. L., Aylward, P. E., Armstrong, P. W., Woodlief, L. H., Lee, K. L., Topol, E. J., VandeWerf, F. Time from symptom onset to treatment and outcomes after thrombolytic therapy Journal of the American College of Cardiology  1996 27:1646-1655  PMID:8636549
  • Langer, A., Goodman, S. G., Topol, E. J., Charlesworth, A., Skene, A. M., Wilcox, R. G., Armstrong, P. W. Late assessment of thrombolytic efficacy (late) study: Prognosis in patients with non-q wave myocardial infarction Journal of the American College of Cardiology  1996 27:1327-1332  DOI:10.1016/0735-1097(96)00012-5  PMID:8626939
  • Barbash, G. I., Reiner, J., White, H. D., Wilcox, R. G., Armstrong, P. W., Sadowski, Z., Morris, D., Aylward, P., Woodlief, L. H., Topol, E. J., Califf, R. M., Ross, A. M. Evaluation of paradoxic beneficial-effects of smoking in patients receiving thrombolytic therapy for acute myocardial-infarction - mechanism of the smokers paradox from the gusto-i trial, with angiographic insights Journal of the American College of Cardiology  1995 26:1222-1229  DOI:10.1016/0735-1097(95)00299-5  PMID:7594035
  • Pilote, L., Califf, R. M., Sapp, S., Miller, D. P., Mark, D. B., Weaver, W. D., Gore, J. M., Armstrong, P. W., Ohman, E. M., Topol, E. J. Regional variation across the united-states in the management of acute myocardial-infarction New England Journal of Medicine  1995 333:565-572  DOI:10.1056/nejm199508313330907  PMID:7623907
  • Vandewerf, F., Topol, E. J., Lee, K. L., Woodlief, L. H., Granger, C. B., Armstrong, P. W., Barbash, G. I., Hampton, J. R., Guerci, A., Simes, R. J., Ross, A. M., Califf, R. M. Variations in patient-management and outcomes for acute myocardial-infarction in the united-states and other countries - results from the gusto trial JAMA-Journal of the American Medical Association  1995 273:1586-1591  DOI:10.1001/jama.273.20.1586  PMID:7745771
  • Mark, D. B., Hlatky, M. A., Califf, R. M., Naylor, C. D., Lee, K. L., Armstrong, P. W., Barbash, G., White, H., Simoons, M. L., Nelson, C. L., Clappchanning, N., Knight, J. D., et al. Cost-effectiveness of thrombolytic therapy with tissue-plasminogen activator as compared with streptokinase for acute myocardial-infarction New England Journal of Medicine  1995 332:1418-1424  DOI:10.1056/nejm199505253322106  PMID:7723799
  • Mark, D. B., Naylor, C. D., Hlatky, M. A., Califf, R. M., Topol, E. J., Granger, C. B., Knight, J. D., Nelson, C. L., Lee, K. L., Clappchanning, N. E., Sutherland, W., Pilote, L., et al. Use of medical resources and quality-of-life after acute myocardial-infarction in canada and the united-states New England Journal of Medicine  1994 331:1130-1135  DOI:10.1056/nejm199410273311706  PMID:7935638
  • Steinberg, J. S., Hochman, J. S., Morgan, C. D., Dorian, P., Naylor, C. D., Theroux, P., Topol, E. J., Armstrong, P. W. Effects of thrombolytic therapy administered 6 to 24 hours after myocardial-infarction on the signal-averaged ecg - results of a multicenter randomized trial Circulation  1994 90:746-752  PMID:8044943
  • Kawai, C., Simoons, M. L., Baigent, C., Lenert, L. A., Collins, R., Lopezsendon, J., Parish, S., Knatterud, G., Visani, L., Halls, H., Nicklas, J., Mead, G., et al. Indications for fibrinolytic therapy in suspected acute myocardial infarction - collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients Lancet  1994 343:311-322  PMID:7905143
  • Ross, A. M., Simoons, M. L., Lundergan, C., Thompson, M., Reiner, J., Deychak, Y., Rohrbeck, S., Coyne, K., Walker, P., Cho, S., Greenhouse, S., Lee, K., et al. The effects of tissue-plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular-function, and survival after acute myocardial-infarction New England Journal of Medicine  1993 329:1615-1622  PMID:8232430
  • Topol, E., Califf, R., Vandewerf, F., Armstrong, P. W., Aylward, P., Barbash, G., Bates, E., Betriu, A., Boissel, J. P., Chesebro, J., Col, J., Debono, D., et al. An international randomized trial comparing 4 thrombolytic strategies for acute myocardial-infarction New England Journal of Medicine  1993 329:673-682  PMID:8204123