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Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization

Academic Article
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Overview

related to degree

  • Breazzano, Steven Philip, Ph.D. in Organic Chemistry, Scripps Research 2009 - 2013
  • Garfunkle, Joie, Ph.D. in Chemistry, Scripps Research 2004 - 2009
  • Trzupek, John, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

  • Shimamura, H.
  • Breazzano, Steven Philip
  • Garfunkle, Joie
  • Kimball, F. S.
  • Trzupek, John
  • Boger, Dale

publication date

  • 2010

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Full details of the initial development and continued examination of a powerful intramolecular palladium(0)-mediated indole annulation for macrocyclization closure of the strained 16-membered biaryl ring system found in complestatin (1, chloropeptin II) and the definition of factors impacting its intrinsic atropodiastereoselectivity are described. Its examination and use in an alternative, second-generation total synthesis of complestatin are detailed in which the order of the macrocyclization reactions was reversed from our first-generation total synthesis. In this approach and with the ABCD biaryl ether ring system in place, the key Larock cyclization was conducted with substrate 36 (containing four phenols, five secondary amides, one carbamate, and four labile aryl chlorides) and provided the product 37 (56%) exclusively as a single atropisomer (>20:1, detection limits) possessing the natural (R)-configuration. In this instance, the complexity of the substrate and the reverse macrocyclization order did not diminish the atropodiastereoselectivity; rather, it provided an improvement over the 4:1 selectivity that was observed with the analogous substrate used to provide the isolated DEF ring system in our first-generation approach. Just as significant, the atroposelectivity represents a complete reversal of the diasteroselectivity observed with analogous macrocyclizations conducted using a Suzuki biaryl coupling.

subject areas

  • Chlorophenols
  • Cyclization
  • Indoles
  • Macrocyclic Compounds
  • Palladium
  • Peptides, Cyclic
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Identity

PubMed Central ID

  • PMC2892899

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja102304p

PubMed ID

  • 20469945
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Additional Document Info

start page

  • 7776

end page

  • 7783

volume

  • 132

issue

  • 22

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