Anti-peptide antibodies detect oncogene-related proteins in urine

Academic Article

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Overview

authors

• Niman, H. L.
• Thompson, A. M. H.
• Yu, A.
• Markman, M.
• Willems, J. J.
• Herwig, K. R.
• Habib, N. A.
• Wood, C. B.
• Houghten, R. A.
• Lerner, Richard

publication date

• 1985

journal

• Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

• Antisera to a number of synthetic peptides predicted from nucleic acid sequences of oncogenes have been used to screen 483 urine samples of cancer patients, pregnant women, and normal controls for the presence of immunologically related proteins. Increased levels of oncogene-related proteins are found during neoplasia and pregnancy. The differential detection of these oncogene-related proteins indicates that panels of monoclonal antibodies may provide a convenient noninvasive means of detecting, classifying, and staging a wide variety of malignancies and may be useful in following fetal development during pregnancy.

subject areas

• Antibodies, Monoclonal
• Antibody Specificity
• Electrophoresis, Polyacrylamide Gel
• Female
• Humans
• Immunosorbent Techniques
• Molecular Weight
• Neoplasm Proteins
• Neoplasms
• Oncogene Proteins, Viral
• Peptide Fragments
• Pregnancy
• Proto-Oncogene Proteins

Identity

International Standard Serial Number (ISSN)

• 0027-8424

Digital Object Identifier (DOI)

• 10.1073/pnas.82.23.7924

PubMed ID

• 3906653

Additional Document Info

start page

• 7924

end page

• 7928

volume

• 82

issue

• 23