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Responsiveness of platelets and coronary-arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogs

Academic Article
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Overview

authors

  • Burke, S. E.
  • Lefer, A. M.
  • Nicolaou, K.C.
  • Smith, G. M.
  • Smith, J. B.

publication date

  • 1983

journal

  • British Journal of Pharmacology  Journal

abstract

  • 1--Platelet-rich plasma (PRP) from humans, cats, dogs (after addition of 10 microM adrenaline), rabbits and guinea-pigs aggregated in response to sodium arachidonate or 9,11-azo-prostaglandin H2, while PRP obtained from sheep was unresponsive to either agent. 2--The stable thromboxane (Tx) analogues, carbocyclic TxA2 (CTA2) and pinane TxA2 (PTA2) significantly inhibited these aggregatory responses in platelets from humans, dogs and guinea-pigs, while PTA2 but not CTA2 produced significant inhibition in cat platelets. The aggregatory response of PRP from rabbits was not significantly blocked by either analogue. 3--CTA2 and the endoperoxide analogue 9,11-methanoepoxy PGH2 (U-46619) constricted coronary arteries from cats, dogs, rabbits and guinea-pigs, while sheep vessels were unresponsive to either analogue. 4--Vasoconstrictor responses to U-46619 were significantly attenuated by PTA2 in vessels from all species. However, constriction produced by CTA2 was blocked significantly only in vessels from cats, dogs and guinea-pigs. 5--These results demonstrate the species differences which exist in the responsiveness of platelets and coronary arteries to thromboxane and endoperoxide analogues. Furthermore, the results illustrate the importance of species selection in the study of thromboxane antagonists for potential therapeutic use.

subject areas

  • Animals
  • Blood Platelets
  • Cats
  • Coronary Vessels
  • Dogs
  • Guinea Pigs
  • Humans
  • In Vitro Techniques
  • Platelet Aggregation
  • Prostaglandin Endoperoxides, Synthetic
  • Rabbits
  • Sheep
  • Species Specificity
  • Thromboxanes
  • Vasoconstriction
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Identity

PubMed Central ID

  • PMC2044703

International Standard Serial Number (ISSN)

  • 0007-1188

PubMed ID

  • 6831115
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Additional Document Info

start page

  • 287

end page

  • 292

volume

  • 78

issue

  • 2

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