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Glutaredoxin is a direct target of oncogenic jun

Academic Article
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Overview

related to degree

  • Iacovoni, Jason Scott, Ph.D. in Biology, Scripps Research 1993 - 2003

authors

  • Goller, M. E.
  • Iacovoni, Jason Scott
  • Vogt, Peter K.
  • Kruse, U.

publication date

  • June 1998

journal

  • Oncogene  Journal

abstract

  • We have analysed differential gene expression in v-jun-transformed chicken embryo fibroblasts (CEF) compared to normal CEF by using the directional tag PCR subtraction method. From a first generation of putative Jun targets four clones were selected for study; they are upregulated in jun-transformed cells. Three of these clones showed homology to known genes: glutaredoxin, growth associated protein (GAP)-43/neuromodulin, and phenobarbital-induced cytochrome P450. The expression of these genes was analysed in fibroblasts transformed by various oncogenes. Expression of the glutaredoxin mRNA could be induced by a Jun-estrogen receptor chimaera in the absence of de novo protein biosynthesis. Based on this observation we conclude that glutaredoxin is a direct target of v-Jun.

subject areas

  • Animals
  • Chick Embryo
  • GAP-43 Protein
  • Gene Expression Regulation
  • Glutaredoxins
  • Oncogene Protein p65(gag-jun)
  • Oxidoreductases
  • Proteins
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Research

keywords

  • cytochrome P450
  • differential expression
  • glutaredoxin
  • growth associated protein (GAP)-43
  • jun
  • subtractive hybridization
  • target gene
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Identity

International Standard Serial Number (ISSN)

  • 0950-9232

Digital Object Identifier (DOI)

  • 10.1038/sj.onc.1201819

PubMed ID

  • 9671415
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Additional Document Info

start page

  • 2945

end page

  • 2948

volume

  • 16

issue

  • 22

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