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New strategies for the design of catalytic antibodies

Academic Article
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Overview

authors

  • Janda, Kim

publication date

  • May 1990

journal

  • Biotechnology Progress  Journal

abstract

  • A new approach is advanced which is aimed at expanding the scope of antibody catalysis. It entails the design and synthesis of haptens that will elicit antibodies to catalyze acyl transfer reactions by a methodology which we term "bait and switch" catalysis. What we have done involves the placement of a point charge on the hapten in close proximity to, or in direct substitution for, a chemical functional group we wish to transform in the respective substrate. The haptenic charge should induce a complementary charge (on an amino acid residue) at the binding site. The substrate will lack this charge but will retain a similar overall structure. The monoclonal antibodies that bind these substrates now have the potential to act as general acids/bases for substrates having hydrolyzable functional groups.

subject areas

  • Acylation
  • Animals
  • Antibodies, Monoclonal
  • Catalysis
  • Electrochemistry
  • Haptens
  • Kinetics
  • Mice
  • Mice, Inbred BALB C
  • Molecular Structure
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Identity

International Standard Serial Number (ISSN)

  • 8756-7938

Digital Object Identifier (DOI)

  • 10.1021/bp00003a002

PubMed ID

  • 1366610
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Additional Document Info

start page

  • 178

end page

  • 181

volume

  • 6

issue

  • 3

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